Is angiotensin II made inside or outside of the cell?

@article{Chai2005IsAI,
  title={Is angiotensin II made inside or outside of the cell?},
  author={Wenxia Chai and A. H. Jan Danser},
  journal={Current hypertension reports},
  year={2005},
  volume={7 2},
  pages={124-7}
}
Angiotensin synthesis at tissue sites is well-established, and depends largely, if not completely, on kidney-derived renin. The exact tissue site of angiotensin generation (extracellular fluid, cell surface, intracellular compartment) is still being debated. In this review, we discuss the various possibilities, taking into consideration the intracellular occurrence/absence of prorenin, renin, angiotensinogen, angiotensin-converting enzyme, and angiotensin receptors; the local activation of… CONTINUE READING

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