Is an immune reaction required for malignant transformation and cancer growth?

  title={Is an immune reaction required for malignant transformation and cancer growth?},
  author={Richmond T. Prehn and Liisa M. Prehn},
  booktitle={Cancer Immunology, Immunotherapy},
Increasing evidence has shown that probably all malignant mouse cells, even those of spontaneous sporadic cancers, are endowed with tumor-specific antigens. Stimulation of cancer growth, rather than inhibition by the immune reaction, is seemingly the prevalent effect in the animal of origin (the autochthonous animal). Small initial dosages of even strong tumor antigens tend to produce stimulatory immune reactions rather than tumor inhibition in any animal. Thus, an immune response at a low… CONTINUE READING

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