Is an elevated concentration of acinar cytosolic free ionised calcium the trigger for acute pancreatitis?

@article{Ward1995IsAE,
  title={Is an elevated concentration of acinar cytosolic free ionised calcium the trigger for acute pancreatitis?},
  author={J B Ward and Ole H Petersen and Spencer A. Jenkins and Robert Sutton},
  journal={Lancet},
  year={1995},
  volume={346 8981},
  pages={1016-9}
}
The pathogenesis of acute pancreatitis is poorly understood, despite well-recognised precipitating factors. Current evidence suggests that the earliest abnormalities of acute pancreatitis arise within acinar cells, but the key intracellular trigger has yet to be identified. Within the pancreas, physiological concentrations of secretagogues bind to G-protein-linked cell-surface receptors on acinar cells, evoking short, oscillatory spikes of acinar cytosolic-free ionised calcium ([Ca2+]i), an… CONTINUE READING
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