Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?

  title={Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?},
  author={Z. Deng and P. Sheehan and S. Chen and Z. Yue},
  journal={Molecular Neurodegeneration},
  • Z. Deng, P. Sheehan, +1 author Z. Yue
  • Published 2017
  • Medicine, Biology
  • Molecular Neurodegeneration
  • Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative disorders that share genetic risk factors and pathological hallmarks. Intriguingly, these shared factors result in a high rate of comorbidity of these diseases in patients. Intracellular protein aggregates are a common pathological hallmark of both diseases. Emerging evidence suggests that impaired RNA processing and disrupted protein homeostasis are two major pathogenic pathways for these diseases… CONTINUE READING

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