Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?

  title={Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?},
  author={Zhiqiang Deng and Patricia R Sheehan and Shi Chen and Zhenyu Yue},
  booktitle={Molecular Neurodegeneration},
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative disorders that share genetic risk factors and pathological hallmarks. Intriguingly, these shared factors result in a high rate of comorbidity of these diseases in patients. Intracellular protein aggregates are a common pathological hallmark of both diseases. Emerging evidence suggests that impaired RNA processing and disrupted protein homeostasis are two major pathogenic pathways for these diseases… CONTINUE READING
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