Is amoxapine an atypical antipsychotic? positron-emission tomography investigation of its dopamine2 and serotonin2 occupancy

@article{Kapur1999IsAA,
  title={Is amoxapine an atypical antipsychotic? positron-emission tomography investigation of its dopamine2 and serotonin2 occupancy},
  author={Shitij Kapur and Raymond Cho and Corey Jones and Gordon Mckay and Robert B Zipursky},
  journal={Biological Psychiatry},
  year={1999},
  volume={45},
  pages={1217-1220}
}
Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [(11)C]DASB PET imaging study.
TLDR
During treatment with clinical doses of paroxetine or citalopram, approximately 80% of 5-HTT receptors are occupied, which is greater than the known physiological range of changes in 5- HTT binding potential but may be necessary for some therapeutic effects.
Amoxapine as an Antipsychotic: Comparative Study Versus Haloperidol
TLDR
Amoxapine may be as effective an antipsychotic as haloperidol as predicted by its affinity for D2 and 5HT2 receptors, supporting earlier studies, but it did not prove to have fewer extrapyramidal side effects than hal operidol, possibly because the baseline scores were very low.
Amoxapine as an Atypical Antipsychotic: A Comparative Study Vs Risperidone
TLDR
Since amoxapine is off-patent, it may be a valuable low-cost alternative to new atypical antipsychotic drugs, particularly in low-income countries where the majority of the patients are still treated with typical antipsychotics.
Reply: Atypical Antipsychotics Mechanisms of Action
TLDR
The observation that olanzapine treatment, which PD patients tolerate poorly owing to motor dysfunction, is virtually free from acute dystonic reactions—a property shared by quetiapine and clozapine, but not by risperidone is intriguing.
Reply: Atypical Antipsychotics Mechanisms of Action
TLDR
The observation that olanzapine treatment, which PD patients tolerate poorly owing to motor dysfunction, is virtually free from acute dystonic reactions—a property shared by quetiapine and clozapine, but not by risperidone is intriguing.
PET measurement of receptor occupancy as a tool to guide dose selection in neuropharmacology: are we asking the right questions?
TLDR
Prospective use of PET to define dosing requirements has been proposed particularly for central nervous system (CNS)-targeted drugs; however, correlations with clinical outcomes have been mostly anecdotal and not causally established.
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