Is agmatine an endogenous anxiolytic/antidepressant agent?

  title={Is agmatine an endogenous anxiolytic/antidepressant agent?},
  author={Feyza Aricioğlu and Hale Z Altunbas},
  journal={Annals of the New York Academy of Sciences},
Agmatine, an endogenous cationic amine, exerts a wide range of biologic effects, but its physiologic role is still to be determined. The aim of the present experiments was to investigate the role of agmatine in anxiety and depression. The forced swim test (FST) and the elevated plus maze (EPM) were used to determine the antidepressant and anxiolytic effects of agmatine in comparison with imipramine (30 mg/kg i.p.). Agmatine (10, 20, 40, 80, or 100 mg/kg, i.p.), saline, or imipramine was given… CONTINUE READING


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