Is adult neurogenesis essential for olfaction?

@article{Lazarini2011IsAN,
  title={Is adult neurogenesis essential for olfaction?},
  author={Françoise Lazarini and Pierre-Marie Lledo},
  journal={Trends in Neurosciences},
  year={2011},
  volume={34},
  pages={20-30}
}
In mammals, new neurons are recruited into restricted brain areas throughout life. Adult-born neurons produced in the subventricular zone of the lateral ventricle migrate rostrally towards the olfactory bulb. Although thousands of neurons reach this central structure every day, the functional impact of their integration into mature circuits remains a matter of debate. Recent investigations have revealed no striking sensory deficits per se when adult bulbar neurogenesis is challenged. However… Expand
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References

SHOWING 1-10 OF 109 REFERENCES
Turnover of Newborn Olfactory Bulb Neurons Optimizes Olfaction
TLDR
It is concluded that adult-generated OB interneurons are continually turned over, rather than simply added, and the precise balance between new and mature interneuronons, set through active selection/elimination processes, is essential for optimizing olfaction. Expand
Distinct Modes of Neuron Addition in Adult Mouse Neurogenesis
TLDR
Genetic fate mapping is used to follow the majority of adult-generated neurons over long periods and demonstrates two distinct modes of neuron addition to the pre-existing network. Expand
Learning and Survival of Newly Generated Neurons: When Time Matters
TLDR
It is found that olfactory training could increase, decrease, or have no effect on the number of surviving newly generated neurons, demonstrating that neuronal elimination is an active process, rather than a simple consequence of nonuse. Expand
Functional Maturation of the First Synapse in Olfaction: Development and Adult Neurogenesis
TLDR
Although maturing cells may offer, transiently, a functionally distinct connection for inputs from the nose, presynaptic function at the first olfactory connection remains remarkably constant in the face of considerable anatomical plasticity. Expand
Watching synaptogenesis in the adult brain.
TLDR
Investigators' observation of synaptogenesis occurring in the adult brain is beginning to shed light on the flexibility that adult neurogenesis offers to mature circuits and the potential contribution of the transient plasticity that new neurons provide toward circuit refinement and adaptation to changing environmental demands. Expand
Neonatal and Adult Neurogenesis Provide Two Distinct Populations of Newborn Neurons to the Mouse Olfactory Bulb
TLDR
It is demonstrated that early postnatal neurogenesis endows the neonate bulbar circuit with newborn GCs that differ morphologically and functionally from those produced in the adult. Expand
Turning Astrocytes from the Rostral Migratory Stream into Neurons: A Role for the Olfactory Sensory Organ
TLDR
Recent evidence for the existence of adult neural stem cells within the RMS is confirmed and considerably extended, and proliferative regulation is investigated via two contrasting manipulations. Expand
Dendritic development and plasticity of adult-born neurons in the mouse olfactory bulb
  • A. Mizrahi
  • Biology, Medicine
  • Nature Neuroscience
  • 2007
TLDR
In vivo two-photon microscopy of lentivirus-labeled newborn neurons was used to directly image their development and maintenance in the olfactory bulb and showed that dendritic formation is highly dynamic with distinct differences between spiny neurons and non-spiny neurons. Expand
Interneurons Produced in Adulthood Are Required for the Normal Functioning of the Olfactory Bulb Network and for the Execution of Selected Olfactory Behaviors
TLDR
The data highlight the importance of adult neurogenesis for the proper functioning of the OB network and imply that new bulbar interneurons are involved in some, but not all, odor-associated tasks. Expand
Importance of newly generated neurons in the adult olfactory bulb for odor discrimination.
TLDR
It is found that the specific reduction in the newly generated interneuron population resulted in an impairment of discrimination between odors, demonstrating that a critical number of bulbar granule cells is crucial only for odor discrimination but not for general olfactory functions. Expand
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