Is action potential threshold lowest in the axon?

@article{Kole2008IsAP,
  title={Is action potential threshold lowest in the axon?},
  author={M. Kole and G. Stuart},
  journal={Nature Neuroscience},
  year={2008},
  volume={11},
  pages={1253-1255}
}
  • M. Kole, G. Stuart
  • Published 2008
  • Biology, Medicine
  • Nature Neuroscience
  • Action potential threshold is thought to be lowest in the axon, but when measured using conventional techniques, we found that action potential voltage threshold of rat cortical pyramidal neurons was higher in the axon than at other neuronal locations. In contrast, both current threshold and voltage threshold of the isolated somato-dendritic spike were substantially higher at the soma. These data indicate that action potential threshold is indeed lowest in the axon. 
    130 Citations

    Figures and Topics from this paper

    Explore Further: Topics Discussed in This Paper

    Signal Processing in the Axon Initial Segment
    • 300
    A Threshold Equation for Action Potential Initiation
    • 164
    • Highly Influenced
    • PDF
    The physiology of the axon initial segment.
    • 141
    Kv1 channels control spike threshold dynamics and spike timing in cortical pyramidal neurones
    • 76
    Electrogenic Tuning of the Axon Initial Segment
    • 104

    References

    SHOWING 1-10 OF 28 REFERENCES
    Ion channel properties underlying axonal action potential initiation in pyramidal neurons
    • 164
    • PDF
    Site of Action Potential Initiation in Layer 5 Pyramidal Neurons
    • 287
    • PDF
    Dynamic spike threshold reveals a mechanism for synaptic coincidence detection in cortical neurons in vivo.
    • R. Azouz, C. M. Gray
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2000
    • 489
    • PDF
    Reliability of spike timing in neocortical neurons.
    • 1,229
    • PDF
    Action potential initiation and propagation in CA3 pyramidal axons.
    • 160
    • PDF