Is a Universal Influenza Virus Vaccine Possible?

@article{Nachbagauer2019IsAU,
  title={Is a Universal Influenza Virus Vaccine Possible?},
  author={Raffael Nachbagauer and Peter Palese},
  journal={Annual review of medicine},
  year={2019}
}
Influenza viruses remain a severe burden to human health because of their contribution to overall morbidity and mortality. Current seasonal influenza virus vaccines do not provide sufficient protection to alleviate the annual impact of influenza and cannot confer protection against potentially pandemic influenza viruses. The lack of protection is due to rapid changes of the viral epitopes targeted by the vaccine and the often suboptimal immunogenicity of current immunization strategies. Major… 
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