Is a Major Neuronal Receptor for Lgi 4-Mediated Schwann Cell Signaling

@inproceedings{zkaynak2016IsAM,
  title={Is a Major Neuronal Receptor for Lgi 4-Mediated Schwann Cell Signaling},
  author={Ekim {\"O}zkaynak and Gina Abell{\'o} and Martine Jaegle and Laura van den Berge and Diana Hamer and Linde Kegel and Siska Driegen and Koji Sagane and John R. Bermingham and Dies Meijer},
  year={2016}
}
The segregation and myelination of axons in the developing peripheral nervous system (PNS), results from a complex series of cellular and molecular interactions between Schwann cells and axons. Previously we identified the Lgi4 gene (Leucine-rich-glioma inactivated4) as an important regulator of myelination in the PNS, and its dysfunction results in arthrogryposis as observed in claw paw mice. Lgi4 is a secreted protein and a member of a small family of proteins that are predominantly expressed… CONTINUE READING

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