Is a Critical CDK 2 Regulator Essential for Proliferation Control in Rb-deficient Cells

@inproceedings{Brugarolas1998IsAC,
  title={Is a Critical CDK 2 Regulator Essential for Proliferation Control in Rb-deficient Cells},
  author={James Brugarolas and Roderick Terry Bronson and Tyler Jacks},
  year={1998}
}
Proliferation in mammalian cells is controlled primarily in the G1-phase of the cell cycle through the action of the G1 cyclin–dependent kinases, CDK4 and CDK2. To explore the mechanism of cellular response to extrinsic factors, specific loss of function mutations were generated in two negative regulators of G1 progression, p21 and pRB. Individually, these mutations were shown to have significant effects in G1 regulation, and when combined, Rb and p21 mutations caused more profound defects in… CONTINUE READING