Is ZFY the sex-determining gene on the human Y chromosome?

  title={Is ZFY the sex-determining gene on the human Y chromosome?},
  author={David C. Page},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  volume={322 1208},
  • David C. Page
  • Published 1988 in
    Philosophical transactions of the Royal Society…
The sex-determining region of the human Y chromosome contains a gene, ZFY, that encodes a zinc-finger protein. ZFY may prove to be the testis-determining factor. There is a closely related gene, ZFX, on the human X chromosome. In most species of placental mammals, we detect two ZFY-related loci: one on the Y chromosome and one on the X chromosome. However… CONTINUE READING