Is VEGF a Key Target of Cotinine and Other Potential Therapies Against Alzheimer Disease?

@article{Echeverra2017IsVA,
  title={Is VEGF a Key Target of Cotinine and Other Potential Therapies Against Alzheimer Disease?},
  author={Valentina Echeverr{\'i}a and George E Barreto and Marco Avila-Rodriguezc and V. V. Tarasov and Gjumrakch Aliev},
  journal={Current Alzheimer research},
  year={2017},
  volume={14 11},
  pages={
          1155-1163
        }
}
BACKGROUND The vascular endothelial growth factor (VEGF) is a neuroprotective cytokine that promotes neurogenesis and angiogenesis in the brain. In animal models, it has been shown that environmental enrichment and exercise, two non-pharmacological interventions that are beneficial decreasing the progression of Alzheimer disease (AD) and depressive-like behavior, enhance hippocampal VEGF expression and neurogenesis. Furthermore, the stimulation of VEGF expression promotes neurotransmission and… CONTINUE READING

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