Is Type 2 Diabetes Mellitus a Risk Factor for Pancreatic Cancer and is Metformin Able to Prevent this Risk

  title={Is Type 2 Diabetes Mellitus a Risk Factor for Pancreatic Cancer and is Metformin Able to Prevent this Risk},
  author={Raffaele Pezzilli},
Type 2 diabetes mellitus represents a public health worldwide emergency and more than 300 million people in the world now have diabetes; it has been associated with cancer in general and for pancreatic cancer in particular. The question of whether diabetes mellitus type 2, is a risk factor for pancreatic cancer is complicated by the possible presence of obesity and by the medication used to treat it (insulin and metformin). We have briefly reviewed the data both for and against the possibility… 



Antidiabetic therapies affect risk of pancreatic cancer.

Diabetic patients who had taken metformin had a significantly lower risk of pancreatic cancer compared with those who had not taken met formin, and insulin or insulin secretagogue use was associated with increased risk of Pancreatic cancer in diabetic patients.

Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals

Metformin can reduce the incidences of several gastroenterological cancers in treated diabetes and depending on gender and cancer type, this effect can be limited to near non-diabetic levels but to varying degrees.

Use of Antidiabetic Agents and the Risk of Pancreatic Cancer: A Case–Control Analysis

Use of metformin was associated with a decreased risk of pancreatic cancer in women only, whereas use of sulfonylureas and of insulin wasassociated with an increased risk of Pancreatic cancer.

Diabetes and risk of pancreatic cancer: a pooled analysis of three large case–control studies

The results show that long-term diabetes, even though risk diminishes over time, remains a risk factor for PC independent of obesity and smoking.

A cohort study of the risk of cancer associated with type 2 diabetes

A cohort study using record-linkage health-care datasets for Tayside, Scotland in 1993–2004 followed up 9577 newly diagnosed patients with type 2 diabetes, and two matched non-diabetic comparators, in the national cancer register.

Body mass index, physical activity and the risk of pancreatic cancer in relation to smoking status and history of diabetes: a large-scale population-based cohort study in Japan–The JPHC study

BMI was inversely associated with risk of pancreatic cancer among men, especially among current male smokers or diabetes patients, but no association was found among women, and leisure-time physical activity was not associated withrisk in either men or women.

Prevention of pancreatic cancer induction in hamsters by metformin.

The results lend further support on the significant role of islet cells in pancreatic carcinogenesis and may explain the association between pancreatic cancer and obesity, which is usually associated with peripheral insulin resistance.

Are Racial Disparities in Pancreatic Cancer Explained by Smoking and Overweight/Obesity?

The inability to attribute excess disease in Blacks to currently known risk factors, even when combined with suspected risks, points to yet undetermined factors that play a role in the disease process.

Risk of Cancer Following Hospitalization for Type 2 Diabetes

The present study assessed subsequent cancer risks in type 2 diabetes patients first hospitalized for this disease at age >39 years. Twenty-four cancer types showed an elevated risk when follow-up