Is Triclosan a neurotoxic agent?

@article{Ruszkiewicz2017IsTA,
  title={Is Triclosan a neurotoxic agent?},
  author={Joanna A Ruszkiewicz and Shaojun Li and Maliya B Rodriguez and Michael Aschner},
  journal={Journal of Toxicology and Environmental Health, Part B},
  year={2017},
  volume={20},
  pages={104 - 117}
}
ABSTRACT Triclosan (TCS) is an antibacterial agent that has been used in many products since 1960s. Given its broad usage as an antiseptic TCS is present ubiquitously in the environment. Trace levels of TCS continue to be detected in many organisms, and it has been shown to be particularly toxic to aquatic species. The mechanisms underlying TCS-mediated toxicity include hormone dyshomeostasis, induction of oxidative stress, apoptosis and inflammation. Although TCS has been considered to be non… 
View on Taylor & Francis
ncbi.nlm.nih.gov
68 Citations
Background Citations
19
Methods Citations
1
Results Citations
1

68 Citations

Citation Type

Citation Type

Triclosan exposure, transformation, and human health effects
TLDR
The aim of this review was to describe TCS exposure routes and levels as well as metabolism and transformation processes, and the burgeoning literature on human health effects associated with T CS exposure, such as reproductive problems, was summarized.
Neurobehavioral toxicity of triclosan in mice.
In vitro and in vivo estrogenic activity of triclosan
TLDR
In vitro and gene-profiling results suggested that TCS exhibited estrogenic activity, which is known to induce endocrine disruption in women and to be consistent with previous reports on triclosan.
Evaluation of subchronic exposure to triclosan on hepatorenal and reproductive toxicities in prepubertal male rats
TLDR
The results indicated that subchronic exposure to excessively high concentrations of 750 mg/kg TCS induced hepatorenal and reproductive toxicities in prepubertal male rats; however, the biological relevance of these findings is questionable as these drug levels are not encountered in the environment.
The Presence of Triclosan in Human Hair Samples in Poland—A Pilot Study
Triclosan (TCS) is an organic substance showing antibacterial action, which is commonly used in many branches of industry, including, among others, cosmetics, pharmaceuticals and the food industry.…
Biomarkers-based assessment of triclosan toxicity in aquatic environment: A mechanistic review.
Developmental and Reproductive Outcomes in Male Rats Exposed to Triclosan: Two-Generation Study
TLDR
The effects of TCS on sperm quality may be related to the exposure window, which includes the programming of reproductive cells that occurs during fetal/neonatal development, as well as the potential bioaccumulation and persistence.
Sublethal effects of triclosan and triclocarban at environmental concentrations in silver catfish (Rhamdia quelen) embryos.
Investigation of the potential effects of triclosan as an endocrine disruptor in female rats: Uterotrophic assay and two-generation study.
Triclosan: antimicrobial mechanisms, antibiotics interactions, clinical applications, and human health.
TLDR
The current understanding of the antimicrobial mechanisms of Triclosan is reviewed, how microbes become resistant to Tricrosan, and the synergistic and antagonistic effects of Trichlosan with different antibiotics are reviewed.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 157 REFERENCES
The commonly used antimicrobial additive triclosan is a liver tumor promoter
TLDR
It is discovered that TCS substantially accelerates hepatocellular carcinoma (HCC) development, acting as a liver tumor promoter, and that the mechanism of TCS-induced mouse liver pathology may be relevant to humans.
Triclosan: environmental exposure, toxicity and mechanisms of action
TLDR
Concern has been raised over TCS's potential for endocrine disruption, as the antimicrobial has been shown to disrupt thyroid hormone homeostasis and possibly the reproductive axis, and there is strong evidence that aquatic species such as algae, invertebrates and certain types of fish are much more sensitive to TCS than mammals.
Occurrence, Efficacy, Metabolism, and Toxicity of Triclosan
TLDR
Data is reviewed on the human exposure, environmental fate, efficacy of anti-microbial activity, absorption, distribution, metabolism and elimination, endocrine disrupting effects, and toxicity of triclosan.
Triclosan: Current Status, Occurrence, Environmental Risks and Bioaccumulation Potential
TLDR
Considering the worldwide application of personal care products containing TCS and inefficient removal and its toxic effects on aquatic organisms, the compound should be considered on the priority list of emerging contaminants and its utilization in all products should be regulated.
Triclosan: A critical review of the experimental data and development of margins of safety for consumer products
TLDR
Exposure to triclosan in consumer products is not expected to cause adverse health effects in children or adults who use these products as intended and a Benchmark Dose (BMDL10) was developed based on kidney toxicity in the hamster.
Assessment of toxic effects of triclosan on the terrestrial snail (Achatina fulica).
Occurrence and toxicity of antimicrobial triclosan and by-products in the environment
TLDR
The excessive use of triclosan is suspected to increase the risk of emergence of TCS-resistant bacteria and the selection of resistant strains, as well as to produce cytotoxic, genot toxic, and endocrine disruptor effects.
Triclosan, an antibacterial agent, increases intracellular Zn(2+) concentration in rat thymocytes: its relation to oxidative stress.
Triclosan (TCS) exposure impairs lipid metabolism in zebrafish embryos.
Pulmonary toxicity screening of triclosan in rats after intratracheal instillation.
TLDR
TCS led to reduction of cell viability with morphological change in lung eptiehelial cells (L2 cell) and TCS may affect responses of acute inflammation and permeability in the lung.
...
1
2
3
4
5
...