Is There an Optimal Formulation and Delivery Strategy for Subunit Vaccines?

@article{Bobbala2016IsTA,
  title={Is There an Optimal Formulation and Delivery Strategy for Subunit Vaccines?},
  author={Sharan Bobbala and Sarah Hook},
  journal={Pharmaceutical Research},
  year={2016},
  volume={33},
  pages={2078-2097}
}
Modern vaccine design has moved away from attenuated or inactivated whole-pathogen vaccines to more pure and defined subunit vaccines. However subunit antigens have poor bioavailability and stability and lack immunogenicity. To overcome these issues subunit vaccines have to be administered in a suitable delivery system in combination with immune stimulants. Many different delivery systems have been developed and investigated each having different modes of action, for example increasing delivery… CONTINUE READING

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Liposome-based adjuvants for subunit vaccines: f o rmu l a t i on s t r a t e g i e s f o r s ubun i t an t i g en s and immunostimulators. Pharmaceutics

  • S Tandrup Schmidt, C Foged, K Smith Korsholm, T Rades, D. Christensen
  • 2016
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