Is There a Role for Antiandrogen Therapy for Hidradenitis Suppurativa? A Systematic Review of Published Data

@article{Nikolakis2019IsTA,
  title={Is There a Role for Antiandrogen Therapy for Hidradenitis Suppurativa? A Systematic Review of Published Data},
  author={Georgios Nikolakis and A Kyrgidis and Christos C. Zouboulis},
  journal={American Journal of Clinical Dermatology},
  year={2019},
  pages={1-11}
}
BackgroundHidradenitis suppurativa/acne inversa is a disease with deep-seated chronic painful nodules, abscesses, and draining sinus tracts, which manifests on the apocrine gland-rich skin areas of the body. Observational findings demonstrate that the disease usually appears after puberty, exhibits pre-menstrual flares in women, improves in pregnancy, and worsens post-partum, which indicates a role of hormones and particularly of androgens in its pathophysiology. Because increased androgen… Expand
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References

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European S1 guideline for the treatment of hidradenitis suppurativa/acne inversa
Hidradenitis suppurativa/acne inversa (HS) is a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle that usually presents after puberty with painful, deep‐seated,Expand
Hidradenitis Suppurativa in 64 Female Patients: Retrospective Study Comparing Oral Antibiotics and Antiandrogen Therapy
TLDR
There is sufficient signal to suggest that a hormonal manipulation approach to therapy should be considered in all women presenting with HS, and female patients presenting withHS should prompt investigations for underlying PCOS and insulin resistance. Expand
Finasteride in Hidradenitis Suppurativa: A "Male" Therapy for a Predominantly "Female" Disease.
TLDR
In hidradenitis suppurativa, finasteride could be considered in adults of both sexes as well as in select female children and adolescents, particularly those with concurrent metabolic and hormonal alterations present. Expand
An Update on Medical Treatment Options for Hidradenitis Suppurativa
TLDR
An overview of most drug treatments reported on for HS is provided, where possible with their mode of action and side effects, and surgical interventions are often needed to achieve remission. Expand
Hidradenitis suppurativa/Acne inversa: an endocrine skin disorder?
TLDR
The current view on the hormonal dysregulation and metabolic syndrome and their role in HS is described. Expand
The Role of Androgens and Estrogens in Hidradenitis Suppurativa - A Systematic Review.
TLDR
The results show that patients with HS do not seem to have increased levels of sex hormones and that their hormone levels lie within the normal range, and antiandrogen treatment could be a valuable approach in treating HS, however randomized control trials are lacking. Expand
Hidradenitis suppurativa: A practical review of possible medical treatments based on over 350 hidradenitis patients.
TLDR
This article summarizes my treatment experience with over 350 HS patients and centers on medical therapies and will only passingly mention surgical and laser treatments. Expand
A Disease-Modifying Approach for Advanced Hidradenitis Suppurativa (Regimen with Metformin, Liraglutide, Dapsone, and Finasteride): A Case Report
TLDR
A 19-year-old female with an 8-year history of progressively debilitating cicatricial HS disease presented with obesity, profound anemia, leukocytosis, increased platelet count, hypoalbuminemia, and elevated liver enzymes, and a combination of metformin, liraglutide, levonorgestrel-ethinyl estradiol, dapsone, and finasteride was initiated. Expand
The SAHA Syndrome
TLDR
The SAHA syndrome generally occurs in young to middle-aged women and involves either the presence of elevated blood levels of androgens or increased androgen-driven peripheral response with normal circulating androgen levels. Expand
The pathogenesis of hidradenitis suppurativa: a closer look at apocrine and apoeccrine glands
TLDR
Observations provide direct evidence in an in vivo model that follicular occlusion by keratinous material, with subsequent active folliculitis and secondary destruction of the skin adnexae and subcutis, occur as an integral step in the pathogenesis of hidradenitis suppurativa. Expand
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