Is There a Role for Antiandrogen Therapy for Hidradenitis Suppurativa? A Systematic Review of Published Data

@article{Nikolakis2019IsTA,
  title={Is There a Role for Antiandrogen Therapy for Hidradenitis Suppurativa? A Systematic Review of Published Data},
  author={Georgios Nikolakis and Athanassios Kyrgidis and Christos C. Zouboulis},
  journal={American Journal of Clinical Dermatology},
  year={2019},
  pages={1-11}
}
BackgroundHidradenitis suppurativa/acne inversa is a disease with deep-seated chronic painful nodules, abscesses, and draining sinus tracts, which manifests on the apocrine gland-rich skin areas of the body. Observational findings demonstrate that the disease usually appears after puberty, exhibits pre-menstrual flares in women, improves in pregnancy, and worsens post-partum, which indicates a role of hormones and particularly of androgens in its pathophysiology. Because increased androgen… 

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Hidradenitis suppurativa/acne inversa (HS) is a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle that usually presents after puberty with painful, deep‐seated,

Hidradenitis Suppurativa in 64 Female Patients: Retrospective Study Comparing Oral Antibiotics and Antiandrogen Therapy

There is sufficient signal to suggest that a hormonal manipulation approach to therapy should be considered in all women presenting with HS, and female patients presenting withHS should prompt investigations for underlying PCOS and insulin resistance.

An Update on Medical Treatment Options for Hidradenitis Suppurativa

An overview of most drug treatments reported on for HS is provided, where possible with their mode of action and side effects, and surgical interventions are often needed to achieve remission.

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This article summarizes my treatment experience with over 350 HS patients and centers on medical therapies and will only passingly mention surgical and laser treatments.

A Disease-Modifying Approach for Advanced Hidradenitis Suppurativa (Regimen with Metformin, Liraglutide, Dapsone, and Finasteride): A Case Report

A 19-year-old female with an 8-year history of progressively debilitating cicatricial HS disease presented with obesity, profound anemia, leukocytosis, increased platelet count, hypoalbuminemia, and elevated liver enzymes, and a combination of metformin, liraglutide, levonorgestrel-ethinyl estradiol, dapsone, and finasteride was initiated.

The SAHA Syndrome

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The pathogenesis of hidradenitis suppurativa: a closer look at apocrine and apoeccrine glands

Observations provide direct evidence in an in vivo model that follicular occlusion by keratinous material, with subsequent active folliculitis and secondary destruction of the skin adnexae and subcutis, occur as an integral step in the pathogenesis of hidradenitis suppurativa.

What causes hidradenitis suppurativa?

To get to the molecular heart of HS pathogenesis, which can only be achieved by a renaissance of solid basic HS research, is the key to developing more effective HS therapy.
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