Is There a Role for Antiandrogen Therapy for Hidradenitis Suppurativa? A Systematic Review of Published Data

@article{Nikolakis2019IsTA,
  title={Is There a Role for Antiandrogen Therapy for Hidradenitis Suppurativa? A Systematic Review of Published Data},
  author={Georgios Nikolakis and Athanassios Kyrgidis and Christos C. Zouboulis},
  journal={American Journal of Clinical Dermatology},
  year={2019},
  pages={1-11}
}
BackgroundHidradenitis suppurativa/acne inversa is a disease with deep-seated chronic painful nodules, abscesses, and draining sinus tracts, which manifests on the apocrine gland-rich skin areas of the body. Observational findings demonstrate that the disease usually appears after puberty, exhibits pre-menstrual flares in women, improves in pregnancy, and worsens post-partum, which indicates a role of hormones and particularly of androgens in its pathophysiology. Because increased androgen… 
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23 Citations
Background Citations
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23 Citations

Hidradenitis Suppurativa in a Patient Affected by Mayer-Rokitansky-Küster-Hauser Syndrome: Insight into the Role of Hormones in HS

HS usually appears after puberty, exhibits premenstrual flare, improves in pregnancy, and worsens postpartum, which indicates a role of hormones and particularly of androgens in its pathophysiology.

Topical finasteride: A potential therapeutic option for hidradenitis suppurativa

This is the first study that describes topical antiandrogen therapy in HS, and 4 patients that received a commercially available topical finasteride on 2–3 HS affected sites at dosage 50 μl of 2275 mg/ml for each area are described.

Cortexolone 17α‐propionate for hidradenitis suppurativa

Clascoterone is most likely to be effective in early stages of disease as it targets the initial pathogenesis of follicular plugging and perifollicular inflammation, and is likely to produce the greatest benefits if initiated as close to disease onset as possible with current safety data supporting its use in those as young as 9 years of age.

New perspectives on the treatment of hidradenitis suppurativa

Evidence for effectiveness of current and emerging HS therapies is described, and new therapeutic options are being studied, targeting different specific cytokines involved in HS pathogenesis.

Multidisciplinary Update on Genital Hidradenitis Suppurativa: A Review.

A variety of reconstructive techniques based on the size and location of the skin deficiency are described, which require a thorough understanding of medical and surgical techniques for prevention, treatment, and reconstruction of genital defects.

The Role of Oral Contraceptive Pills in Hidradenitis Suppurativa: A Cohort Study

OCPs might be effective for improving AN count in women with HS, and women whose HS worsens in relation to the menstrual cycle and have a shorter disease may benefit more from the therapeutic effect of OCPs.

Spironolactone in Dermatology: Uses in Acne, Hidradenitis Suppurativa, Female Pattern Hair Loss, and Hirsutism

What causes hidradenitis suppurativa ?—15 years after

This anniversary article of 43 research‐performing authors from all around the globe in the official journal of the European Hidradenitis Suppurativa Foundation e.V. summarizes the evidence of the intense HS clinical and experimental research during the last 15 years in all aspects of the disease.

Hidradenitis Suppurativa and Comorbid Disorder Biomarkers, Druggable Genes, New Drugs and Drug Repurposing—A Molecular Meta-Analysis

Evidence is provided for the importance of molecular studies to advance the knowledge regarding pathogenesis, future treatment and biomarker-supported clinical course follow-up in HS.

Target molecules for future hidradenitis suppurativa treatment

The most promising molecules currently under investigation from a pathophysiological and clinical point of view are addressed in the treatment of hidradenitis suppurativa/acne inversa.

References

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Hidradenitis suppurativa/acne inversa (HS) is a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle that usually presents after puberty with painful, deep‐seated,…

Hidradenitis Suppurativa in 64 Female Patients: Retrospective Study Comparing Oral Antibiotics and Antiandrogen Therapy

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Observations provide direct evidence in an in vivo model that follicular occlusion by keratinous material, with subsequent active folliculitis and secondary destruction of the skin adnexae and subcutis, occur as an integral step in the pathogenesis of hidradenitis suppurativa.

What causes hidradenitis suppurativa?

To get to the molecular heart of HS pathogenesis, which can only be achieved by a renaissance of solid basic HS research, is the key to developing more effective HS therapy.
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