Is There a Recreational Misuse Potential for Pregabalin? Analysis of Anecdotal Online Reports in Comparison with Related Gabapentin and Clonazepam Data

@article{Schifano2011IsTA,
  title={Is There a Recreational Misuse Potential for Pregabalin? Analysis of Anecdotal Online Reports in Comparison with Related Gabapentin and Clonazepam Data},
  author={Fabrizio Schifano and Stefano D’Offizi and Michele Piccione and Ornella Corazza and Paolo Deluca and Zoe Davey and Giuditta di Melchiorre and Lucia di Furia and Mag{\'i} Farr{\'e} and Liv Flesland and Miia Mannonen and Aino Majava and Stefania Pagani and Teuvo Peltoniemi and Holger Siemann and Arvid Skutle and Marta Torrens and Cinzia Pezzolesi and Peer van der Kreeft and Norbert Scherbaum},
  journal={Psychotherapy and Psychosomatics},
  year={2011},
  volume={80},
  pages={118 - 122}
}
1 „ReDNet‟ and „Psychonaut Web Mapping‟ Projects; University of Hertfordshire School of Pharmacy, Hatfield, UK 2 Psychiatry and Clinical Psychology Department, Umberto I, “La Sapienza” University of Rome Medical School, Rome, Italy; Viale Regina Elena 244, 00161, Rome,Italy; doffizi.stefano@gmail.com; michele.piccione@uniroma1.it 3 Psychonaut Web Mapping Project; National Addiction Centre, Institute of Psychiatry, King's College London, London, UK; 4 Windsor Walk; SE5 AF; paolo.deluca@kcl.ac.uk… Expand
Toxicological Relevance of Pregabalin in Heroin Users: A Two-Year Post-Mortem Population Study.
TLDR
The magnitude of the difference in use may not be sufficient to conclude that heroin users are at substantially greater risk of pregabalin toxicity compared to non-heroin users, but results indicate that heroinusers who take PGL are more likely to use multiple depressant drugs, hence increasing the risk of multi-drug toxicity and death. Expand
A Decade of Gabapentinoid Misuse: An Analysis of the European Medicines Agency’s ‘Suspected Adverse Drug Reactions’ Database
TLDR
Analysis of proportional reporting ratios for drug abuse/dependence/intentional product misuse values seem to indicate that these adverse drug reactions were more frequently reported for pregabalin compared with gabapentin, especially in patients with a history of substance misuse. Expand
Pregabalin Use Among Users of Illicit Drugs: A Cross-Sectional Survey in Southern Germany
TLDR
Use of pregabalin is common among users of illicit drugs in large parts of southern Germany, with motives for use, acquisition, and mode of use suggesting misuse. Expand
Acute Psychotic Episode Associated with the Intake of a Testosterone-Enhancer Herbal Mixture Purchased Online
TLDR
This represents the first literature description of a range of psychopathological disturbances possibly associated with the intake of Universal N1-T and a psychotic episode which apparently occurred in association with self-administration of this particular herbal mixture is reported. Expand
Misuse and Mortality Related to Gabapentin and Pregabalin are Being Under-Estimated: A Two-Year Post-Mortem Population Study.
TLDR
GBP and PGL are being significantly under reported in fatalities, both drugs are extensively used with opioids and the prevalence of PGL in heroin users is highly significant. Expand
How prevalent and severe is addiction on GABAmimetic drugs in an elderly German general hospital population? Focus on gabapentinoids, benzodiazepines, and z-hypnotic drugs.
OBJECTIVE Gabapentinoids (GPT) are reported to be increasingly misused by opioid- and polydrug-users, but the addictive potential of GPT outside of these populations remains understudied.Expand
Misuse of pregabalin: Case series and literature review
TLDR
It is suggested that pregabalin should carefully prescribe in patients with a possible previous history of drug abuse, and a particular population that are abuser of cocaine, alcohol and/or heroin is identified. Expand
Commentary on "A Call for Caution in Prescribing Gabapentin to Individuals with Concurrent Polysubstance Abuse: A Case Report".
  • D. Kahn
  • Medicine
  • Journal of psychiatric practice
  • 2019
TLDR
This case report describes a patient with long-term polysubstance abuse and new onset gabapentin dependence and demonstrates the need for increased surveillance of gABapentin prescribing. Expand
Pregabalin abuse for enhancing sexual performance: case discussion and literature review
  • M. Osman, P. Casey
  • Medicine, Psychology
  • Irish Journal of Psychological Medicine
  • 2014
TLDR
A 55-year-old patient with a background history of multiple psychoactive substances misuse who elaborated on his own personal experience of pregabalin abuse consumed a month’s supply of this medication over 2 days and realized an enhancement in sexual desire and excitement. Expand
Pregabalin and addiction: lessons from published cases
TLDR
PRG, however, is currently under investigation for the treatment of substance-related disorders such as benzodiazepine withdrawal treatment as well as relapse prevention in alcohol and benzadiazepine dependence, making the potential of PRG to cause addictive behaviors particularly delicate. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 69 REFERENCES
[Psychotropic drug addiction: consumption study of specific population by the survey OPPIDUM 2004 from the CEIP network].
TLDR
The main trends observed were an increasing interest for opioid maintenance treatment by methadone versus buprenorphine high dosage, some changes in illicit drugs uses and changes in the grading of the most consumpted benzodiazepines (decrease in flunitrazepam consumption and increase in clonazepam Consumption). Expand
Assessment of abuse potential of benzodiazepines from a prescription database using ‘doctor shopping’ as an indicator
TLDR
The DSI can be used to assess the relative abuse liability of benzodiazepines and to detect signals of new patterns of abuse in settings where centralized records of prescription or deliveries are available for the great majority of patients. Expand
Estimation of clonazepam abuse liability: a new method using a reimbursed drug database
TLDR
The clustering method can be used to assess the magnitude of abuse liability of clonazepam and is also interesting for following its evolution, two important keys for assessing patterns of abuse. Expand
Drugs on the web; the Psychonaut 2002 EU project
TLDR
This represents the first review which is both comprehensive and multilingual of the online available information on psychoactive compounds and health professionals may need to be aware of the web being a new drug resource for information and possibly purchase. Expand
[Pregabalin and its potential for abuse].
TLDR
Assessment of the substance pregabaline's potential for abuse indicates that pre gabaline is associated with less physical and psychological dependence than benzodiazepines. Expand
Psychoactive drug or mystical incense? Overview of the online available information on Spice products
TLDR
The appeal of Spice to online customers was associated with its legal status, lack of detection in biological samples, ease of online access and cannabis-like effects, and the powerful synthetic THC receptor agonists that seem to account for the psychoactive effects. Expand
Efficacy and safety of pregabalin in alcohol dependence
TLDR
Pregabalin shows promise as a treatment for alcohol dependence and safety parameters did not show any significant variation during treatment, in what is the first study concerning the efficacy and safety of pregabalin in current alcoholics. Expand
Pregabalin for the treatment of generalized anxiety disorder: a novel pharmacologic intervention
TLDR
Randomized, controlled trials confirm that pregabalin is superior to placebo and comparable with lorazepam, alprazolam and venlafaxine for the treatment of patients with moderate-to-severe GAD. Expand
Issues in the clinical use of benzodiazepines: potency, withdrawal, and rebound.
  • G. Chouinard
  • Psychology, Medicine
  • The Journal of clinical psychiatry
  • 2004
TLDR
Although as a class benzodiazepines act rapidly and are well tolerated, their use presents clinical issues such as dependence, rebound anxiety, memory impairment, and discontinuation syndrome. Expand
Atypical Antipsychotics: CATIE Study, Drug-Induced Movement Disorder and Resulting Iatrogenic Psychiatric-Like Symptoms, Supersensitivity Rebound Psychosis and Withdrawal Discontinuation Syndromes
TLDR
To achieve optimal maintenance treatment with antipsychotic treatment, and to reduce or withdraw antipsychotics effectively, it is proposed that syndromes associated with discontinuing antippsychotics, such as supersensitivity psychosis, from true relapse are distinguished. Expand
...
1
2
3
4
5
...