Is There a Positive Side to T Cell Exhaustion?

@inproceedings{Pawelec2019IsTA,
  title={Is There a Positive Side to T Cell Exhaustion?},
  author={Graham Pawelec},
  booktitle={Front. Immunol.},
  year={2019}
}
T cell "exhaustion" describes a state of late-stage differentiation usually associated with active prevention of functionality via ligation of negative signaling receptors on the cell surface, and which can be reversed by blocking these interactions. This contrasts with T cell "senescence," which has been defined as a state that is maintained by intrinsic internal cell signaling (caused by DNA damage or other stresses) and which can be reversed pharmacologically. Interventions to alleviate… CONTINUE READING
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