Is Stability Prediction Possible for Protein Drugs? Denaturation Kinetics of β- Galactosidase in Solution

Abstract

Denaturation and aggregation kinetics of Aspergillus oryzae β-galactosidase in solution were studied in order to determine whether the stability of protein drugs can be predicted. Denaturation of β-galactosidase, monitored by measuring enzyme activity, conformed to first-order kinetics, whereas aggregation of the denatured form, monitored by high… (More)
DOI: 10.1023/A:1018955031042

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Cite this paper

@article{Yoshioka1994IsSP, title={Is Stability Prediction Possible for Protein Drugs? Denaturation Kinetics of β- Galactosidase in Solution}, author={Sumie Yoshioka and Yukio Aso and Ken-ichi Izutsu and Shigeo Kojima}, journal={Pharmaceutical Research}, year={1994}, volume={11}, pages={1721-1725} }