Is SPARC an evolutionarily conserved collagen chaperone?

  title={Is SPARC an evolutionarily conserved collagen chaperone?},
  author={Nathalie Martinek and Jaffer Shahab and Jaro Sodek and Maurice J. Ringuette},
  journal={Journal of dental research},
  volume={86 4},
The construction of collagen fiber scaffolds, which provide the structural integrity of the extracellular matrix of connective tissues and basement membranes, is initiated by a complex mechanism of protein-folding, whereby pro-collagen alpha-chains are assembled into triple-helical procollagen molecules. This unique assembly of the procollagen molecules is guided by several endoplasmic reticulum resident molecular chaperones, including HSP47, which dissociates from procollagen molecules prior… CONTINUE READING