Is Retinal Metabolic Dysfunction at the Center of the Pathogenesis of Age-related Macular Degeneration?

@inproceedings{Lveillard2019IsRM,
  title={Is Retinal Metabolic Dysfunction at the Center of the Pathogenesis of Age-related Macular Degeneration?},
  author={Thierry L{\'e}veillard and Nancy Philp and Florian Sennlaub},
  booktitle={International journal of molecular sciences},
  year={2019}
}
The retinal pigment epithelium (RPE) forms the outer blood⁻retina barrier and facilitates the transepithelial transport of glucose into the outer retina via GLUT1. Glucose is metabolized in photoreceptors via the tricarboxylic acid cycle (TCA) and oxidative phosphorylation (OXPHOS) but also by aerobic glycolysis to generate glycerol for the synthesis of phospholipids for the renewal of their outer segments. Aerobic glycolysis in the photoreceptors also leads to a high rate of production of… CONTINUE READING

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