Is Replication the Gold Standard for Validating Genome-Wide Association Findings?

@article{Liu2008IsRT,
  title={Is Replication the Gold Standard for Validating Genome-Wide Association Findings?},
  author={Yong-Jun Liu and Christopher J. Papasian and Jian-feng Liu and J. Paul Hamilton and Hong-Wen Deng},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={820 - 822}
}
With the advent of genome-wide association (GWA) studies, researchers are hoping that reliable genetic association of common human complex diseases/traits can be detected. Currently, there is an increasing enthusiasm about GWA and a number of GWA studies have been published. In the field a common practice is that replication should be used as the gold standard to validate an association finding. In this article, based on empirical and theoretical data, we emphasize that replication of GWA… CONTINUE READING

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New insights into the genetics of body weight.

Current opinion in clinical nutrition and metabolic care • 2008
View 1 Excerpt

Required sample size and nonreplicability thresholds for heterogeneous genetic associations.

Proceedings of the National Academy of Sciences of the United States of America • 2008
View 2 Excerpts

A genome - wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

R Sladek, G Rocheleau, J Rung, C Dina, L Shen
Science • 2007

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