Is Replication the Gold Standard for Validating Genome-Wide Association Findings?

  title={Is Replication the Gold Standard for Validating Genome-Wide Association Findings?},
  author={Yong-Jun Liu and Christopher J. Papasian and Jian-feng Liu and J. Paul Hamilton and Hong-Wen Deng},
  journal={PLoS ONE},
  pages={820 - 822}
With the advent of genome-wide association (GWA) studies, researchers are hoping that reliable genetic association of common human complex diseases/traits can be detected. Currently, there is an increasing enthusiasm about GWA and a number of GWA studies have been published. In the field a common practice is that replication should be used as the gold standard to validate an association finding. In this article, based on empirical and theoretical data, we emphasize that replication of GWA… CONTINUE READING

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