Is Radiation Therapy for Keloids Acceptable? The Risk of Radiation-Induced Carcinogenesis
@article{Ogawa2009IsRT, title={Is Radiation Therapy for Keloids Acceptable? The Risk of Radiation-Induced Carcinogenesis}, author={Rei Ogawa and Sumiko Yoshitatsu and Ken Yoshida and Tsuguhiro Miyashita}, journal={Plastic and Reconstructive Surgery}, year={2009}, volume={124}, pages={1196-1201} }
Background: Keloids have been treated by using radiation for over a century, and it is currently suggested that keloids are best treated by a combination of surgery and postoperative radiation therapy, although randomized controlled trials testing this are still lacking. However, plastic surgeons tend to avoid radiation therapy for keloids for fear of inducing malignant tumors. Thus, the authors searched for previous reports of associations between carcinogenesis and keloid radiation therapy…
141 Citations
Adjuvant Radiotherapy for Keloids
- Medicine, PhysicsAesthetic Plastic Surgery
- 2021
This review summarized the published literature of adjuvant radiotherapy for keloids involving mechanism, timing, dose, fractions, and complications, etc., which may facilitate clinical decision making.
RADIATION THERAPY for the Adjunctive Treatment of Surgically Excised Keloids: A Review.
- MedicineThe Journal of clinical and aesthetic dermatology
- 2017
Dermatologists should be well versed in radiotherapy to provide optimal care for patients with recalcitrant keloids, as radiotherapy appears useful as an adjuvant therapy to surgically excised keloid treatment.
Radiation Therapy in Keloids Treatment: History, Strategy, Effectiveness, and Complication
- MedicineChinese medical journal
- 2017
Both past and present evidence support the idea that combination therapy of radiation and surgical therapy is safe and feasible, and the optimization of treatment strategy was based on different radiation types and should take dose, fractions, interval, and complications into consideration, which will decrease the rate of recurrence and increase the level of satisfaction.
Optimizing Radiotherapy for Keloids: A Meta-Analysis Systematic Review Comparing Recurrence Rates Between Different Radiation Modalities
- Medicine, PhysicsAnnals of plastic surgery
- 2017
The results of this study reinforce postoperative radiotherapy as effective management for keloids as brachytherapy was the most effective of the currently used radiation modalities.
Assessing keloid recurrence following surgical excision and radiation
- MedicineBurns & trauma
- 2020
The results of this review indicate keloidectomy followed by radiation therapy provide satisfactory recurrence rates; however, clinical studies evaluating these treatments do not describe treatment outcomes or use different definitions of keloids recurrence, making comparisons across studies difficult.
Surgical excision and postoperative radiotherapy for keloids
- MedicineScars, burns & healing
- 2019
The overall keloid recurrence rate is now below 10% and electron beam (β-ray) irradiation is currently the best due to its excellent dose distribution and safety.
Radiation Therapy Following Total Keloidectomy: A Retrospective Study over 11 Years
- MedicineArchives of plastic surgery
- 2015
A retrospective analysis to identify the appropriate radiation dose and fractionation in post-keloidectomy radiotherapy for ear lobe keloids suggests 1,500 cGy of radiation in three fractions following keloidectomy for ear lobes.
Surgery and Radiation Therapy for Keloids and Hypertrophic Scars
- Medicine
- 2019
There is substantial evidence now that surgery followed by radiation therapy can successfully manage keloids and hypertrophic scars with low levels of recurrence, and the development of a standard international algorithm for treating pathological scars is warranted.
Surgical Excision with Adjuvant Irradiation for Treatment of Keloid Scars: A Systematic Review
- MedicinePlastic and reconstructive surgery. Global open
- 2015
The evidence confirms the recommendations stated by authors in the recent years and the quality of this evidence is limited, due to the lack of high-quality randomized studies, but more randomized studies will generate stronger recommendations.
Consensus Guidelines on the Use of Superficial Radiation Therapy for Treating Nonmelanoma Skin Cancers and Keloids.
- MedicineThe Journal of clinical and aesthetic dermatology
- 2019
Consensus was reached that SRT is a safe and effective treatment for basal cell and squamous cell carcinomas and should be considered as the first-line form of radiation treatment.
References
SHOWING 1-10 OF 52 REFERENCES
Biologically Effective Doses of Postoperative Radiotherapy in the Prevention of Keloids
- MedicineStrahlentherapie und Onkologie
- 2005
The results of this study indicate that for effectively treating keloids postoperatively, a relatively high dose must be applied in a short overall treatment time.
Keloids treated with excision followed by radiation therapy.
- MedicineJournal of the American Academy of Dermatology
- 1994
The treatment of 783 keloid scars by iridium 192 interstitial irradiation after surgical excision.
- MedicineInternational journal of radiation oncology, biology, physics
- 1993
Prevention of Earlobe Keloid Recurrence with Postoperative Corticosteroid Injections Versus Radiation Therapy A Randomized, Prospective Study and Review of the Literature
- MedicineDermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
- 1996
Although a statistically significant difference was not observed, radiotherapy appeared to be more effective than steroid injections in preventing keloid recurrence, and patients were much more likely to complete treatment than with corticosteroid injections.
Postoperative interstitial radiotherapy of keloids by iridium 192: a retrospective study of 46 treated scars.
- MedicineDermatology
- 1997
Postoperative interstitial radiotherapy represents an effective, unconstraining and safe treatment for keloids if the contraindications are respected.
The risks of treating keloids with radiotherapy.
- MedicineThe British journal of radiology
- 1999
A case of a patient who developed bilateral breast carcinomas almost 30 years after treatment of chest wall keloids with radiotherapy is reported, indicating the safety of this approach to the management of keloid scars.
Combined Surgical Excision and Radiation Therapy for Keloid Treatment
- MedicineThe Journal of craniofacial surgery
- 2007
The combined treatment of surgical excision and postoperative electron beam irradiation is effective for scar quality and reducing the recurrence rate in long-term follow up.
Superficial X‐Ray Therapy in Keloid Management: A Retrospective Study of 24 Cases and Literature Review
- MedicinePlastic and reconstructive surgery
- 1995
It is concluded that superficial x-ray therapy does reduce the rate of postexcisional keloid recurrence, and the need for better controls in reporting on superficialx-ray Therapy in keloids management is stressed.
Radiotherapy in the Management of Keloids
Clinical Experience with Electron Beam Irradiation and Comparison with X-Ray Therapy
- MedicineStrahlentherapie und Onkologie
- 2002
Electron radiation therapy is superior to kilovoltage irradiation for treating keloids due to better dose distribution in tissue, and therefore less radiation burden to the organs at risk.
Role of ionizing irradiation for 393 keloids.
- MedicineInternational journal of radiation oncology, biology, physics
- 1988