Is Propranolol Effective in Primary Polydipsia?

  title={Is Propranolol Effective in Primary Polydipsia?},
  author={Yasuhiro Kishi and Hisashi Kurosawa and S Endo},
  journal={The International Journal of Psychiatry in Medicine},
  pages={315 - 325}
Objective: Psychiatric patients presenting with polydipsia are often difficult to treat with standard psychiatric interventions. Pharmacological intervention was attempted in these patients based on the hypothesis that angiotensin II, a potent dipsinogen, may be involved in the drinking behavior of patients with polydipsia. Beta-blockers inhibit renin release (and thus indirectly angiotensin II) by blocking beta receptors in the kidney. Methods: Three patients were identified as excessive water… 
Primary polydipsia in the medical and psychiatric patients
This MD-PhD thesis aims at contributing to improving the pathophysiological understanding of, to characterize complications in, and to find treatment options for patients with primary polydipsia by evaluating glucagon-like peptide-1 receptor agonists, medications used to treat type 2 diabetes mellitus and obesity, as a treatment option.
Hiponatremia in the practice of a psychiatrist. Part 2: psychogenic polydipsia
Mentally ill patients, especially those with chronic schizophrenia, should be monitored for psychogenic polydipsia and the concomitant hyponatremia and a suitable reduction of fluid intake by them.
Pharmacological treatments for psychosis-related polydipsia.
The trials offer little to the clinician hoping to treat psychosis-related polydipsia with drugs, except that further evaluative studies need to be conducted in this area.
Reply to comment on: Sailer CO, et al. Primary polydipsia in the medical and psychiatric patient: characteristics, complications and therapy.
An overview of the pathophysiology, characteristics, complications, and outcomes of patients with PP in the medical and psychiatric patient is provided.
Primary polydipsia: Update.
Polyuria and Polydipsia
The water deprivation test is an established test to differentiate between cranial and renal DI, and synthetic ADH still remains the treatment of choice for cranial DI.
Clozapine-associated Pseudomembranous Colitis
This is the first reported case of pseudomembranous colitis in a patient after prolonged clozapine administration, which was further complicated by postoperative ileus.
Polidipsia e Intoxicación Hídrica en la Esquizofrenia Crónica. Revisión de la Bibliografía.
A revision of the major issues about polydipsia and water intoxication is made. Your history, actual hypothesis, clinical aspects, diagnosys and management are considered.
An Unquenchable Thirst
His laboratory values are significant for a sodium level of 110 mEq/L (reference range: 135 to 145 mEQ/L), indicating hyponatremia.
Thermal analytical characterization of mixtures of antipsychotic drugs with various excipients for improved drug delivery
Antipsychotics are a class of psychiatric medication that is primarily effective at reducing psychosis symptoms, particularly in schizophrenia and bipolar disorders. This study aims to formulate


Pharmacologic approaches to psychogenic polydipsia: Case reports
Polydipsia and hyponatremia in psychiatric patients.
Evaluation of psychiatric patients with polydipsia includes a search for other medical causes of polyd dipsia, polyuria, hyponatremia, and SIADH, and treatment modalities currently available include fluid restriction and medications.
Involvement of the α2-adrenergic system in polydipsia in schizophrenic patients: a pilot study
Findings indicate clearly that the α2-adrenergic system is involved in the drinking behavior of schizophrenic patients, and mianserin appears to be clinically useful in treating such patients with polydipsia.
Involvement of the alpha2-adrenergic system in polydipsia in schizophrenic patients: a pilot study.
Findings indicate clearly that the alpha2-adrenergic system is involved in the drinking behavior of schizophrenic patients, and mianserin appears to be clinically useful in treating such patients with polydipsia.
Somatic findings in patients with psychogenic polydipsia.
An epidemiologic investigation found a 17.5% prevalence of psychogenic polydipsia in 241 hospitalized psychiatric patients and revealed such associated disorders as sporadic convulsive seizures, comatose states, hydronephrosis, enuresis/urinary incontinence, projectile type vomiting, malnutrition and, in one case, cardiomegaly and edema.
Death from Self‐Induced Water Intoxication among Patients with Schizophrenic Disorders
Evidence of antecedent severe hyposthenuria and postmortem vitreous humor hyponatremia of less than 120 mEq/1 are stongly supportive of the diagnosis of death due to SIWIS.
Self-induced water intoxication: a comparison of 34 cases with matched controls.
Of 2201 psychiatric patients in public facilities in a single metropolitan area evaluated for polydipsia, 34 (1.5%) were found to have a history of self-induced water intoxication, and most had the primary diagnosis of schizophrenia.
Urinary tract abnormalities due to chronic psychogenic polydipsia.
Of 10 patients who excreted urine with low specific gravity and had chronic psychogenic polydipsia, five had urinary tract abnormalities, ranging from large bladders with large postvoid residuals to