Is Pepsin a Reliable Marker of Laryngopharyngeal Reflux? A Systematic Review

@article{CalvoHenrquez2017IsPA,
  title={Is Pepsin a Reliable Marker of Laryngopharyngeal Reflux? A Systematic Review},
  author={Christian Calvo-Henr{\'i}quez and Christian Calvo-Henr{\'i}quez and Alberto Ruano-Ravi{\~n}a and Pedro Vaamonde and Gabriel Mart{\'i}nez-Capoccioni and Carlos Martin-Martin},
  journal={Otolaryngology–Head and Neck Surgery},
  year={2017},
  volume={157},
  pages={385 - 391}
}
Objective Laryngopharyngeal reflux (LPR) is a common illness of otolaryngology visits. Over the past few years, pepsin has become a promising marker of LPR. The objective of the present research is to analyze the existing literature using pepsin as a diagnostic tool of LPR through a systematic review. Data Sources PubMed (Medline), Trip Database, Cochrane Library, EMBASE, SUMsearch, and Web of Science. Review Methods The outcome assessed was the presence of pepsin in LPR patients. We included… Expand
Salivary peptest for laryn gopharyngeal reflux and gastroesophageal reflux disease A systemic review and meta-analysis
Background: A rapid lateral flow test (Peptest) to detect pepsin in saliva/sputum has been considered as a valuable method for diagnosing laryngopharyngeal reflux (LPR) and gastroesophageal refluxExpand
Evaluation and Management of Laryngopharyngeal Reflux Disease: State of the Art Review
  • J. Lechien, L. Akst, +10 authors M. Vaezi
  • Medicine
  • Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 2019
TLDR
The important heterogeneity across studies in LPR diagnosis continues to make it difficult to summarize a single body of thought, and LPR treatment should evolve to a more personalized regimen according to individual patient characteristics. Expand
The Diagnostic Usefullness of the Salivary Pepsin Test in Symptomatic Laryngopharyngeal Reflux.
TLDR
The PEP-test is a simple, inexpensive, non-invasive and easily reproducible test that should be considered as an alternative diagnosis tool for LPR diagnosis when there is a clinical suspicion of LPR disease, but on subjects with negative results it should be complemented with more complex tests such as the 24-hour dual-channel pH-metry. Expand
In Response to Saliva Pepsin Detection and Proton Pump Inhibitor Response in Suspected Laryngopharyngeal Reflux
TLDR
Patients with a history of allergy and other chronic inflammatory disorders were excluded from the study, and saliva pepsin detection could be useful in differentiating diseases of this type from LPR. Expand
Pepsin in Saliva as a Diagnostic Marker for Gastroesophageal Reflux Disease: A Meta-Analysis
TLDR
It was showed that pepsin in saliva has moderate diagnostic value for GERD, and is not as helpful as previously thought. Expand
Laryngopharyngeal reflux disease: clinical presentation, diagnosis and therapeutic challenges in 2018
TLDR
Diagnosis remains controversial despite improvement in impedance and availability of pepsin detection in daily practice, and the addition of alginate or magaldrate to proton pump inhibitors should be considered. Expand
In Reference to Saliva Pepsin Detection and Proton Pump Inhibitor Response in Suspected Laryngopharyngeal Reflux
TLDR
According to the lack of evidence about the Peptest’s validity, future researchers who study epidemiological characteristics of the PePTest should include patients with a demonstrated LPR diagnosis, and should consider the diet during the testing period for LPR patients and healthy controls. Expand
Laryngopharyngeal Reflux: Current Concepts on Etiology and Pathophysiology and Its Role in Dysphagia
TLDR
Dysphagia and LPR both have significant overlap with numerous disease entities, and few studies show that managing LPR-related dysphagia may improve with surgical intervention if there is no improvement with conservative management. Expand
Detection of Pepsin in Oral Secretions of Infants with and without Laryngomalacia
TLDR
Pepsin in saliva appears to be associated with laryngomalacia, suggesting a role for salivary pepsin as a noninvasive marker of LPR in patients with laryngeal reflux, and future studies will determine the utility of this test in larygomalacia. Expand
Involvement of Laryngopharyngeal Reflux in Ocular Diseases: A State-of-the-Art Review.
TLDR
The role of laryngopharyngeal reflux in the development of ocular disorders has not yet been demonstrated and data are limited and heterogeneous, so future studies using objective testing for diagnosis and pepsin detection into the tear and nasal mucosa are needed in order to explore this potential relationship. Expand
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