Is Pepsin a Reliable Marker of Laryngopharyngeal Reflux? A Systematic Review

@article{CalvoHenrquez2017IsPA,
  title={Is Pepsin a Reliable Marker of Laryngopharyngeal Reflux? A Systematic Review},
  author={Christian Calvo-Henr{\'i}quez and Christian Calvo-Henr{\'i}quez and Alberto Ruano-Ravi{\~n}a and Pedro Vaamonde and Gabriel Mart{\'i}nez-Capoccioni and Carlos Martin-Martin},
  journal={Otolaryngology–Head and Neck Surgery},
  year={2017},
  volume={157},
  pages={385 - 391}
}
Objective Laryngopharyngeal reflux (LPR) is a common illness of otolaryngology visits. Over the past few years, pepsin has become a promising marker of LPR. The objective of the present research is to analyze the existing literature using pepsin as a diagnostic tool of LPR through a systematic review. Data Sources PubMed (Medline), Trip Database, Cochrane Library, EMBASE, SUMsearch, and Web of Science. Review Methods The outcome assessed was the presence of pepsin in LPR patients. We included… 

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Pepsin in saliva appears to be associated with laryngomalacia, suggesting a role for salivary pepsin as a noninvasive marker of LPR in patients with laryngeal reflux, and future studies will determine the utility of this test in larygomalacia.

Is the pepsin immunohistochemical staining of laryngeal lesions an available way for diagnosing laryngopharyngeal reflux

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Optimal Timing of the Salivary Pepsin Test for the Diagnosis of Laryngopharyngeal Reflux.

Salivary pepsin testing combined with waking, 1’h and 2 h after breakfast and lunch, and 1”h after dinner has almost the same diagnostic value as MTPSPT, and testing at these time points can be an effective method for diagnosing LPR.
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