Is Nitric Oxide Decrease Observed with Naphthoquinones in LPS Stimulated RAW 264.7 Macrophages a Beneficial Property?

@inproceedings{Pinho2011IsNO,
  title={Is Nitric Oxide Decrease Observed with Naphthoquinones in LPS Stimulated RAW 264.7 Macrophages a Beneficial Property?},
  author={B. Pinho and Carla Roberta Macedo de Sousa and Patr{\'i}cia Valent{\~a}o and Paula B Andrade},
  booktitle={PloS one},
  year={2011}
}
The search of new anti-inflammatory drugs has been a current preoccupation, due to the need of effective drugs, with less adverse reactions than those used nowadays. Several naphthoquinones (plumbagin, naphthazarin, juglone, menadione, diosquinone and 1,4-naphthoquinone), plus p-hydroquinone and p-benzoquinone were evaluated for their ability to cause a reduction of nitric oxide (NO) production, when RAW 264.7 macrophages were stimulated with lipopolysaccharide (LPS). Dexamethasone was used as… CONTINUE READING
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Molecular mechanisms of quinone cytotoxicity

  • PJ O’Brien
  • Chem Biol Interact
  • 1991
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