Is Na+ required for the binding of dopamine, amphetamine, tyramine, and octopamine to the human dopamine transporter?

Abstract

The role of Na+ in the recognition of blockers by the dopamine transporter is accomodated by a model with a cation site that overlaps with the blocker binding domain, and a distal Na+ site that interacts with this cation site and perhaps with the blocker binding domain itself. The present study addresses the application of this model to the recognition of… (More)
DOI: 10.1007/s00210-001-0526-6

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Cite this paper

@article{Li2002IsNR, title={Is Na+ required for the binding of dopamine, amphetamine, tyramine, and octopamine to the human dopamine transporter?}, author={Li-bin Li and Xiao-nan Cui and Maarten E A Reith}, journal={Naunyn-Schmiedeberg's Archives of Pharmacology}, year={2002}, volume={365}, pages={303-311} }