Is Mossy Fiber Sprouting a Potential Therapeutic Target for Epilepsy?

@article{Cavarsan2018IsMF,
  title={Is Mossy Fiber Sprouting a Potential Therapeutic Target for Epilepsy?},
  author={Clarissa Fantin Cavarsan and Jackeline Moraes Malheiros and Clement Hamani and Imad M. Najm and Luciene Covolan},
  journal={Frontiers in Neurology},
  year={2018},
  volume={9}
}
Mesial temporal lobe epilepsy (MTLE) caused by hippocampal sclerosis is one of the most frequent focal epilepsies in adults. It is characterized by focal seizures that begin in the hippocampus, sometimes spread to the insulo-perisylvian regions and may progress to secondary generalized seizures. Morphological alterations in hippocampal sclerosis are well defined. Among them, hippocampal sclerosis is characterized by prominent cell loss in the hilus and CA1, and abnormal mossy fiber sprouting… 

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