Is Melphalan Dose Adjustment According to Ideal Body Weight Useful in Isolated Limb Infusion for Melanoma?

@article{Huismans2012IsMD,
  title={Is Melphalan Dose Adjustment According to Ideal Body Weight Useful in Isolated Limb Infusion for Melanoma?},
  author={Anna M. Huismans and Hidde Maarten Kroon and Lauren Elaine Haydu and Peter C. A. Kam and John F. Thompson},
  journal={Annals of Surgical Oncology},
  year={2012},
  volume={19},
  pages={3050-3056}
}
BackgroundIsolated limb infusion (ILI), introduced in 1992, is a technique used to deliver regional chemotherapy to treat advanced melanoma confined to a limb. Adjusting melphalan dose according to ideal body weight (IBW) has been proposed as a method of decreasing limb toxicity without compromising outcome. The current study analyzed this proposed dose adjustment.MethodsWe reviewed 99 consecutive patients with lower extremity melanomas treated by ILI at our institution between May 1998 and… CONTINUE READING
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