Is Mediated via Akt and p 70 s 6 Kinase Cell-Survival Signaling Myocardial Protection by Insulin at Reperfusion Requires Early Administration

@inproceedings{Jonassen2001IsMV,
  title={Is Mediated via Akt and p 70 s 6 Kinase Cell-Survival Signaling Myocardial Protection by Insulin at Reperfusion Requires Early Administration},
  author={Anne Kristine Jonassen and Michael N. Sack and Ole Danbolt Mj\os and Derek M Yellon},
  year={2001}
}
The “metabolic cocktail” comprising glucose-insulin-potassium administrated at reperfusion reduces infarct size in the in vivo rat heart. We propose that insulin is the major component mediating this protection and acts via Akt prosurvival signaling. This hypothesis was studied in isolated perfused rat hearts (measuring infarct size to area of risk [%]) subjected to 35 minutes regional myocardial ischemia and 2 hours reperfusion. Insulin administered at the onset of reperfusion attenuated… CONTINUE READING
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