Is MS an inflammatory or primary degenerative disease?

  title={Is MS an inflammatory or primary degenerative disease?},
  author={Jacek Losy},
  booktitle={Journal of Neural Transmission},
Multiple sclerosis (MS) is characterized by multiple areas of inflammation, demyelination and neurodegeneration. Multiple molecular and cellular components mediate neuroinflammation in MS. They involve: adhesion molecules, chemokines, cytokines, matalloproteases and the following cells: CD4+ T cells, CD8+ T cells, B cells, microglia and macrophages. Infiltrating Th1 CD4+ T cells secrete proinflammatory cytokines. They stimulate the release of chemokines, expression of adhesion molecules and can… CONTINUE READING
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