Is Iodine A Gatekeeper of the Integrity of the Mammary Gland?

  title={Is Iodine A Gatekeeper of the Integrity of the Mammary Gland?},
  author={Carmen Aceves and Brenda Anguiano and Guadalupe Delgado},
  journal={Journal of Mammary Gland Biology and Neoplasia},
This paper reviews evidence showing iodine as an antioxidant and antiproliferative agent contributing to the integrity of normal mammary gland. Seaweed is an important dietary component in Asian communities and a rich source of iodine in several chemical forms. The high consumption of this element (25 times more than in Occident) has been associated with the low incidence of benign and cancer breast disease in Japanese women. In animal and human studies, molecular iodine (I2) supplementation… 

Iodine stimulates estrogen receptor singling and its systemic level is increased in surgical patients due to topical absorption

Excess iodine intake may be an unfavorable factor in breast cancer by stimulation of ER-α transcriptional activity, as indicated by analyses of clinical urine samples from breast cancer patients undergoing surgery.


The iodine privation prevented normal maturation of breast tissue in the studied lot of 3 weeks old female mice, and iodine seems to play an important role in breast development in young female mammals.

Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR)

Together, these data demonstrate that the antineoplasic effect of iodine involves 6-IL formation and PPARγ induction.

Iodine in Evolution of Salivary Glands and in Oral Health

The authors suggest that the trophic, antioxidant and apoptosis-inductor actions and the presumed antitumour activity of iodides might be important for prevention of oral and salivary glands diseases, as for some other extrathyroidal pathologies.

Toxicology of iodine: A mini review

In this literature review, the data concerning genetic toxicology and the influence of these compounds on tumor rates in epidemiological and experimental studies are analyzed.

IodIne In evolutIon of SalIvary GlandS and In oral HealtH

The authors suggest that the trophic, antioxidant and apoptosis-inductor actions and the presumed antitumour activity of iodides might be important for prevention of oral and salivary glands diseases, as for some other extrathyroidal pathologies.

Evolution of Dietary Antioxidants: Role of Iodine

Thyroid cells phylogenetically derived from primitive gastroenter ic cells, which during evolution of vertebrates migrated and specialized in uptake and storage of i odo-compounds in a new follicular “thyroidal” structure, for a better adaptation to iodine-defici ent terrestrial environment are reviewed.

The Role of Iodine for Thyroid Function in Lactating Women and Infants.

The importance of appropriate definitions of optimal iodine nutrition and the need for more data assessing the risk of mild iodine deficiency for thyroid disorders during the first 2 years in life are highlighted.



Is there a role for iodine in breast diseases?

It is hypothesized that dietary iodine deficiency is associated with the development of mammary pathology and cancer. A review of the literature on this correlation and of the author's own work on

Hypothesis: Iodine, selenium and the development of breast cancer

There is suggestive evidence for a preventive role for iodine and selenium in breast cancer, but rigorous retrospective and prospective studies are needed to confirm this hypothesis.

Role of iodine in antioxidant defence in thyroid and breast disease

The role played in thyroid hormonogenesis by iodide oxidation to iodine (organification) is well established and less compelling evidence exists of a role for iodide as an antioxidant in the breast.

Different tissue responses for iodine and iodide in rat thyroid and mammary glands

Oral administered I2 or I− in trace doses with similar iodine availability caused different histopathological and endocrine patterns in thyroid and mammary glands of ID rats, indicating that replacement therapy with various forms of iodine are tissue-specific.

Suppressive effect of iodine on DMBA‐induced breast tumor growth in the rat

In the comparison of tissue iodine content in growth‐suppressive tumors with that in nonsuppressive tumors, the former showed a much higher iodine content, which suggests that direct uptake of inorganic iodine by breast tumors led to the suppression of tumor growth.

Prolactin regulation of the pendrin-iodide transporter in the mammary gland.

It is suggested that the prolactin stimulation of pendrin activity is an essential element in the prolactic stimulation of iodide uptake into milk, which is also essential for iodide accumulation in milk.

The mammary gland iodide transporter is expressed during lactation and in breast cancer

The results indicate that the mammary gland sodium/iodide symporter may be an essential breast cancer marker and that radioiodide should be studied as a possible option in the diagnosis and treatment of breast cancer.

Site of lodination in rat mammary gland

  • J. Strum
  • Chemistry, Medicine
    The Anatomical record
  • 1978
The ability of the mammary gland to take up and organically bind radioiodide was studied in non‐pregnant, pregnant, and lactating rats and it was found that the presence and location of this enzyme was correlated with the ability to iodinate.

Effect of Insulin on Iodide Uptake in Mouse Mammary Gland Explants

Insulin is an important and essential hormone in the lactogenic hormone complex for regulating iodine uptake in the mammary gland, but maximal expression of iodide uptake is only expressed when all three lactogenic hormones are present.