Is IL-1 a good therapeutic target in the treatment of arthritis?

  title={Is IL-1 a good therapeutic target in the treatment of arthritis?},
  author={Danielle Burger and J A Dayer and Gaby Palmer and Cem Gabay},
  journal={Best practice & research. Clinical rheumatology},
  volume={20 5},
Inflammation is an important homeostatic mechanism that limits the effects of infectious agents. However, inflammation might be self-damaging and therefore has to be tightly controlled or even abolished by the organism. Interleukin 1 (IL-1) is a crucial mediator of the inflammatory response, playing an important part in the body's natural responses and the development of pathological conditions leading to chronic inflammation. While IL-1 production may be decreased or its effects limited by so… CONTINUE READING
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