Is HIV drug resistance a limiting factor in the development of anti-HIV NNRTI and NRTI-based vaginal microbicide strategies?

@article{Martnez2006IsHD,
  title={Is HIV drug resistance a limiting factor in the development of anti-HIV NNRTI and NRTI-based vaginal microbicide strategies?},
  author={J. Alfredo Mart{\'i}nez and Paul Coplan and Mark A. Wainberg},
  journal={Antiviral research},
  year={2006},
  volume={71 2-3},
  pages={343-50}
}
Antiviral drugs that act at specific sites within the HIV life cycle have important rationale for development as anti-HIV microbicides. However, to be effective, such drugs must act by directly interfering with viral enzymatic function and eliminate the ability of HIV to mediate infection. Compounds that are developed as microbicides must have high potency, and should ideally not be well absorbed from the vaginal cavity in order to minimize any potential problems of drug resistance. Such… CONTINUE READING

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