Is FKBP5 a genetic marker of affective psychosis? A case control study and analysis of disease related traits

@article{Gawlik2006IsFA,
  title={Is FKBP5 a genetic marker of affective psychosis? A case control study and analysis of disease related traits},
  author={Micha Gawlik and Kerstin Moller-Ehrlich and Meinhard Mende and Michael Jovnerovski and Sven Jung and Burkhard Emanuel Jabs and Michael Knapp and Gerald Stoeber},
  journal={BMC Psychiatry},
  year={2006},
  volume={6},
  pages={52 - 52}
}
BACKGROUND A dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been proposed as an important pathogenic factor in depression. Genetic variants of FKBP5, a protein of the HPA system modulating the glucocorticoid receptor, have been reported to be genetically associated with improved response to medical treatment and an increase of depressive episodes. METHODS We examined three single nucleotide polymorphisms (SNPs) in FKBP5, rs4713916 in the proposed promoter region, rs1360780… CONTINUE READING