Is DOPA a neurotransmitter?

  title={Is DOPA a neurotransmitter?},
  author={Yoshimi Misu and Yoshio Goshima and Takeaki Miyamae},
  journal={Trends in pharmacological sciences},
  volume={23 6},
Historically, 3,4-dihydroxyphenylalanine (DOPA) has been considered to be an inert amino acid that alleviates the symptoms of Parkinson's disease by its conversion to dopamine via the enzyme aromatic L-amino acid decarboxylase. In contrast to this generally accepted idea, we propose that DOPA itself is a neurotransmitter and/or neuromodulator in addition to being a precursor of dopamine. Several criteria such as synthesis, metabolism, active transport, existence, physiological release… CONTINUE READING


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