Is DOPA-Responsive Hypokinesia Responsible for Bimanual Coordination Deficits in Parkinson’s Disease?

Abstract

Bradykinesia is a well-documented DOPA-responsive clinical feature of Parkinson's disease (PD). While amplitude deficits (hypokinesia) are a key component of this slowness, it is important to consider how dopamine influences both the amplitude (hypokinesia) and frequency components of bradykinesia when a bimanually coordinated movement is required. Based on… (More)
DOI: 10.3389/fneur.2013.00089

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