Is DNA repair compromised in Alzheimer's disease?

  title={Is DNA repair compromised in Alzheimer's disease?},
  author={Vladislav Davydov and Lawrence Arthur Hansen and Deborah A. Shackelford},
  journal={Neurobiology of aging},
  volume={24 7},
Mammalian cells utilize multiple mechanisms to repair DNA damage that occurs during normal cellular respiration and in response to genotoxic stress. This study sought to determine if chronic oxidative stress proposed to occur during Alzheimer's disease alters the expression or activity of DNA double-strand break repair or base excision repair proteins. Double-strand break repair requires DNA-dependent protein kinase, composed of a catalytic subunit, DNA-PKcs, and a regulatory component, Ku. Ku… CONTINUE READING


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