Is Chlormethiazole Neuroprotective in Experimental Global Cerebral Ischemia? A Microdialysis and Behavioral Study

@article{Thaminy1997IsCN,
  title={Is Chlormethiazole Neuroprotective in Experimental Global Cerebral Ischemia? A Microdialysis and Behavioral Study},
  author={Seddik Thaminy and J. M. Reymann and Nathalie Heresbach and Herv{\'e} Allain and Dani{\`e}le Bentu{\'e}-FerrerD. Bentu{\'e}-Ferrer},
  journal={Pharmacology Biochemistry and Behavior},
  year={1997},
  volume={56},
  pages={737-745}
}
Chlormethiazole, an anticonvulsive agent, has been shown to have a possible neuroprotective effect against cerebral ischemia. In addition, chlormethiazole inhibits methamphetamine-induced release of dopamine, protecting against this neurotransmitter's neurotoxicity. The aim of this work was to ascertain whether, in experimental cerebral ischemia, chlormethiazole administration attenuated the ischemia-induced rise of the extracellular concentration of aminergic neurotransmitters and whether it… CONTINUE READING
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