Is CTLA-4 a master switch for peripheral T cell tolerance?


The CD28/CTLA-4 and B7 families of cell surface molecules regulate a complex pathway of T cell signals that profoundly affect peripheral T cell responses. On the one hand, CD28/B7-mediated T cell costimulation is essential for the development and maintenance of T cell responses. In contrast, the prevailing data suggest that the engagement of CTLA-4 with the same B7 ligands down-regulates the initiation and progression of immune responses. This commentary examines the role of CTLA-4-mediated signaling in the regulation of the immune response, leading to the hypothesis that the CTLA-4/B7 interaction plays an essential role in the establishment of peripheral self-tolerance as well as the regulation of normal T cell immunity.

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@article{Bluestone1997IsCA, title={Is CTLA-4 a master switch for peripheral T cell tolerance?}, author={Jeffrey A Bluestone}, journal={Journal of immunology}, year={1997}, volume={158 5}, pages={1989-93} }