Is Autoimmune Thyroiditis Part of the Genetic Vulnerability (or an Endophenotype) for Bipolar Disorder?

  title={Is Autoimmune Thyroiditis Part of the Genetic Vulnerability (or an Endophenotype) for Bipolar Disorder?},
  author={Ronald Vonk and Astrid C. van der Schot and Ren{\'e} S. Kahn and Willem A. Nolen and Hemmo A. Drexhage},
  journal={Biological Psychiatry},
Bipolar disorder and antithyroid antibodies: review and case series
Offspring of bipolar subjects were found more vulnerable to develop thyroid antibodies independently from the vulnerability to develop psychiatric disorders, and a twin study suggested thyroid antibodies among possible endophenotypes for bipolar disorder.
The seroprevalence of antithyroid peroxidase antibodies in bipolar families and bipolar twins: results from two longitudinal studies
Whether TPO-Abs are stable over time, are associated with lithium-exposure, share a common genetic background with BD and are related to psychopathology is investigated to support the view of a possible common (autoimmune) etiology of severe mood disorders and chronic recurrent infections and autoimmunity, including thyroid autoIMmunity.
Genetic and environmental influences on circulating NK and T cells and their relation to bipolar disorder
The results confirm that BD is the result of a complex interaction between various genetic and environmental risk factors, in which T and NK cells act as important intermediate immune players.
Monozygotic twin pairs discordant for Hashimoto's thyroiditis share a high proportion of thyroid peroxidase autoantibodies to the immunodominant region A. Further evidence for genetic transmission of epitopic “fingerprints”
The data indicate that the propensity to produceAutoantibodies directed against the IDR-A epitope of TPO is genetically determined, which may have implications with respect to inheritance of autoantibody specificities in other autoimmune diseases.
Thyroid autoimmunity in bipolar disorder: A systematic review.
Thyroglobulin antibodies and risk of readmission at one year in subjects with bipolar disorder
Maternal history of autoimmune disease in children presenting with tics and/or obsessive–compulsive disorder
Association between autoimmune thyroiditis and depressive disorder in psychiatric outpatients
A strong association between anti-TPO levels, which are considered to be of diagnostic value for autoimmune thyroiditis (in combination with a hypoechoic thyroid in ultrasonography) with uni- or bipolar depression is demonstrated.
Bipolar disorder - from endophenotypes to treatment.
The discovery of BAD endophenotypes can enhance early diagnosis, prevent errors in treatment and help elucidate the genetic vulnerability for this grave disease.


Endophenotypes in bipolar disorder.
Findings in patients with bipolar disorder that may eventually be useful as endophenotypes include abnormal regulation of circadian rhythms, response to sleep deprivation, P300 event-related potentials, behavioral responses to psychostimulants and other medications, Response to cholinergics, increase in white matter hyperintensities, and biochemical observations in peripheral mononuclear cells.
Molecular genetics of bipolar disorder
It is almost certain that over the next few years the identification of bipolar susceptiblity genes will have a major impact on the understanding of disease pathophysiology.
Are autoimmune thyroid dysfunction and depression related?
It is concluded that women with elevated TPO-Ab levels are especially vulnerable to depression, whereas postmenopausal status does not increase the risk of depression.
Autosomal dominant transmission of autoantibodies to thyroglobulin and thyroid peroxidase.
In a study of 16 families with autoimmune thyroid disease, autoantibodies to thyroid peroxidase (TPO) were found to be inherited as a dominant Mendelian trait in females with reduced penetrance in males.
Thyroid and adrenal axis in major depression: a controlled study in outpatients.
When compared with matched control subjects, outpatients with major depression had slightly higher serum TSH, while urinary cortisol levels were similar, and it was observed lower serum cortisol in atypical depression than in non-atypical Depression.
Prevalence of antithyroid antibodies in mood disorders
Psychiatric inpatients with unipolar depression does not appear to be associated with an excessive rate of antithyroid antibodies; however thyroid autoimmunity may be weakly associated with subtypes of bipolar disorder in which depressive symptoms are prominent.
The frequency of thyroid antibodies in fibromyalgia patients and their relationship with symptoms
Age and postmenopausal status seemed to be associated with thyroid autoimmunity in FM patients, and the presence of thyroid autoIMmunity had no relationship with the depression scores of FM patients.
The association between autoimmune thyroiditis, autoimmune gastritis and type 1 diabetes.
Screening DM1 patients and their relatives (particularly females) for thyroid autoimmunity is recommended, and whether autoimmune thyroiditis and autoimmune gastritis patients should be screened for islet Ab is not clarified.