Is Aspirin a Cause of Reye’s Syndrome?

@article{Orlowski2002IsAA,
  title={Is Aspirin a Cause of Reye’s Syndrome?},
  author={J. Orlowski and U. Hanhan and M. Fiallos},
  journal={Drug Safety},
  year={2002},
  volume={25},
  pages={225-231}
}
Reye’s syndrome was a rare disease which appeared suddenly in the early 1950s and disappeared just as suddenly in the late 1980s. An association between Reye’s syndrome and the ingestion of aspirin (acetylsalicylic acid) was claimed, although no proof of causation was ever established. The presence of salicylates in the blood or urine of Reye’s syndrome patients has not been demonstrated, and no animal model of Reye’s syndrome has been developed where aspirin causes the disease. It is clear… Expand
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