Is 1-aminobenzotriazole an appropriate in vitro tool as a nonspecific cytochrome P450 inactivator?

@article{Linder2009Is1A,
  title={Is 1-aminobenzotriazole an appropriate in vitro tool as a nonspecific cytochrome P450 inactivator?},
  author={Collette D Linder and Nicole A. Renaud and James Matthew Hutzler},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2009},
  volume={37 1},
  pages={10-3}
}
1-Aminobenzotriazole (1-ABT) is generally considered to be a nonselective mechanism-based inactivator of both human and non-human cytochrome P450 (P450) enzymes. Thus, 1-ABT is routinely used when conducting in vitro reaction phenotyping studies with new chemical entities in drug discovery to decipher P450 from non-P450-mediated metabolism. Experiments with pooled human liver microsomes (HLMs) demonstrated that carbon monoxide binding, although substantially reduced after a 30-min preincubation… CONTINUE READING

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