Is α‐lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity

@article{PetersenShay2008IsA,
  title={Is $\alpha$‐lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity},
  author={Kate Petersen Shay and R{\'e}gis Moreau and Eric J. Smith and Tory M. Hagen},
  journal={IUBMB Life},
  year={2008},
  volume={60}
}
The chemical reduction and oxidation (redox) properties of α‐lipoic acid (LA) suggest that it may have potent antioxidant potential. A significant number of studies now show that LA and its reduced form, dihydrolipoic acid (DHLA), directly scavenge reactive oxygen species (ROS) and reactive nitrogen species (RNS) species and protect cells against a host of insults where oxidative stress is part of the underlying etiology. However, owing to its limited and transient accumulation in tissues… Expand
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References

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Pro-oxidant actions of α-lipoic acid and dihydrolipoic acid
There is strong accumulating evidence that a α-lipoic acid (LA) supplement is good insurance, and would markedly improve human health. LA is readily absorbed from the diet, transported to cells andExpand
α-Lipoic Acid: A Metabolic Antioxidant Which Regulates NF-κB Signal Transduction and Protects Against Oxidative Injury
Although the metabolic role of alpha-lipoic acid has been known for over 40 years, it is only recently that its effects when supplied exogenously have become known. Exogenous alpha-lipoic acid isExpand
Pro-oxidant actions of a-lipoic acid and dihydrolipoic acid
There is strong accumulating evidence that a a-lipoic acid (LA) supplement is good insurance, and would markedly improve human health. LA is readily absorbed from the diet, transported to cells andExpand
alpha-Lipoic acid as a biological antioxidant.
TLDR
The properties of lipoate are reviewed in terms of reactions with reactive oxygen species; interactions with other antioxidants; beneficial effects in oxidative stress models or clinical conditions. Expand
Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress.
TLDR
The known biochemical properties of alpha-Lipoic acid are reviewed with particular reference to how LA may be an effective agent to ameliorate certain pathophysiologies of many chronic diseases. Expand
Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation.
TLDR
Investigation of the interplay between lipoic acid and glutathione in microsomal Fe2+ (10 microM)/ascorbate (0.2 mM)-induced lipid peroxidation shows that this effect can be ascribed completely to reduction of GSSG to GSH by reduced lipoIC acid, which may provide a rationale for the therapeutic effectiveness of lipoics acid. Expand
Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization
TLDR
Flow cytometric analysis of freshly prepared human peripheral blood lymphocytes reveals that lipoic acid acts mainly to normalize a subpopulation of cells severely compromised in thiol status rather than to increase thiol content beyond physiological levels, suggesting it may have clinical relevance in restoration of severely glutathione deficient cells. Expand
(R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis.
TLDR
It is demonstrated that LA is an effective agent to restore both the age-associated decline in thiol redox ratio as well as increase cerebral GSH levels that otherwise decline with age. Expand
α‐Lipoic acid inhibits TNF‐a‐induced NF‐κB activation and adhesion molecule expression in human aortic endothelial cells
Endothelial activation and monocyte adhesion are initiating steps in atherogenesis thought to be caused in part by oxidative stress. The metabolic thiol antioxidant a‐lipoic acid has been suggestedExpand
Alpha-lipoic acid in liver metabolism and disease.
TLDR
Experimental studies and clinical trials in the last 5 years have provided new and consistent evidence for the therapeutic role of antioxidant alpha-lipoic acid in the treatment of insulin resistance and diabetic polyneuropathy, and should encourage clinicians to use alpha- Lipoic Acid in diseases affecting liver in which oxidative stress is involved. Expand
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