Is "Leptin Resistance" Another Key Resistance To Manage In Type 2 Diabetes?

  title={Is "Leptin Resistance" Another Key Resistance To Manage In Type 2 Diabetes?},
  author={Juan Salazar and Mervin Ch{\'a}vez-Castillo and Joselyn Rojas and {\'A}ngel Ortega and Manuel Nava and Jos{\'e} L. P{\'e}rez and Milagros Rojas and Cristobal Espinoza and Maricarmen Chac{\'i}n and Yaneth Herazo and Liss{\'e} Angarita and Diana Rojas and Luis D’Marco and Valmore Berm{\'u}dez},
  journal={Current diabetes reviews},
Although novel pharmacological options for the treatment of type 2 diabetes mellitus (DM2) have been observed to modulate the functionality of several key organs in glucose homeostasis, successful regulation of insulin resistance (IR), body weight management, and pharmacological treatment of obesity remain notable problems in endocrinology. Leptin may be a pivotal player in this scenario, as an adipokine which centrally regulates appetite and energy balance. In obesity, excessive caloric intake… 
5 Citations

Exploring Phytotherapeutic Alternatives for Obesity, Insulin Resistance and Diabetes Mellitus.

This review comprises an exploration of currently available preclinical and clinical research on the role of MH in the management of obesity, IR, and DM.

Leptin resistance before and after obesity: evidence that tissue glucose uptake underlies adipocyte enlargement and liver steatosis/steatohepatitis in Zucker rats from early-life stages

In fa/fa Zucker rats, leptin resistance leads to glucose intolerance, mainly due to hepatic glucose overproduction, preceding obesity, and explaining pancreatic and intestinal hormonal changes and fat accumulation in adipocytes and hepatocytes.

Leptin and its receptor gene polymorphism as a target for pharmacotherapy in T2DM and COPD

This review aims to identify opportunities to optimize drug therapy in comorbid pathology to increase the effectiveness of pharmacotherapy, improve the prognosis and outcomes of concomitant diseases, and slow the progression of one or a combination of diseases.

TNF-α Antagonizes the Effect of Leptin on Insulin Secretion through FOXO1-Dependent Transcriptional Suppression of LepRb in INS-1 Cells

The results of this study reveal that TNF-α-induced LepRb downregulated in pancreatic β cells, and demonstrate that transcriptional reduction of FOXO1 might be the primary mechanism underlying T NF-α promoting INS-1E leptin resistance and β cell dysfunction, and FoxO1 may be a novel target for treatingβ cell dysfunction in obesity-induced hyperinsulinemia and T2DM.

Alzheimer’s disease and type 2 diabetes mellitus: Pathophysiologic and pharmacotherapeutics links

The hyperphosphorylation of tau and the formation of neurofibrillary tangles have been associated with the dysfunction of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in the nervous tissues, contributing to the implementation of overlapping pharmacological interventions based on the use of insulin and antidiabetic drugs, or azeliragon, amylin, among others, which have shown possible beneficial effects in diabetic patients diagnosed with AD.



Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy Homeostasis

A greater understanding of the overlapping functions of leptin and insulin in the central nervous system is vital to understand the associated physiological and pathophysiological states.

The cellular and molecular bases of leptin and ghrelin resistance in obesity

The molecular mechanisms underpinning resistance to leptin and ghrelin are discussed and how they can be exploited as targets for pharmacological management of obesity are discussed.

The role of leptin in health and disease

The objective was to provide a comprehensive and state-of-the-art review about the importance of leptin to maintain the homeostasis and during pathological conditions.

Leptin-signaling pathways and leptin resistance.

Interestingly, some leptin functions remain intact in the leptin-resistant state, such as cardiovascular leptin effects, and the appearance of selective leptin resistance is mirrored by the observation that cellular leptin resistance has been found only in some subpopulations of hypothalamic LRb neurons.

Leptin, diabetes, and the brain

It is suggested that defects or dysfunction in leptin signaling may contribute to the etiology of diabetes and the possibility that either leptin or downstream targets of leptin may have therapeutic potential for the treatment of diabetes is raised.