Is "Leptin Resistance" Another Key Resistance To Manage In Type 2 Diabetes?

@article{Salazar2019IsR,
  title={Is "Leptin Resistance" Another Key Resistance To Manage In Type 2 Diabetes?},
  author={Juan Salazar and Mervin Ch{\'a}vez-Castillo and Joselyn Rojas and {\'A}ngel Ortega and Manuel Nava and Jos{\'e} L. P{\'e}rez and Milagros Rojas and Cristobal Espinoza and Maricarmen Chac{\'i}n and Yaneth Herazo and Liss{\'e} Angarita and Diana Rojas and Luis D’Marco and Valmore Berm{\'u}dez},
  journal={Current diabetes reviews},
  year={2019}
}
Although novel pharmacological options for the treatment of type 2 diabetes mellitus (DM2) have been observed to modulate the functionality of several key organs in glucose homeostasis, successful regulation of insulin resistance (IR), body weight management, and pharmacological treatment of obesity remain notable problems in endocrinology. Leptin may be a pivotal player in this scenario, as an adipokine which centrally regulates appetite and energy balance. In obesity, excessive caloric intake… 
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