Irvalec Inserts into the Plasma Membrane Causing Rapid Loss of Integrity and Necrotic Cell Death in Tumor Cells

@article{MolinaGuijarro2011IrvalecII,
  title={Irvalec Inserts into the Plasma Membrane Causing Rapid Loss of Integrity and Necrotic Cell Death in Tumor Cells},
  author={J. M. Molina-Guijarro and A. Macias and Carolina Garc{\'i}a and E. Vegas Mu{\~n}oz and L. Garc{\'i}a-Fern{\'a}ndez and M. David and L. N{\'u}{\~n}ez and J. F. Mart{\'i}nez-Leal and V. Moneo and C. Cuevas and M. Lillo and Carlos Villalobos Jorge and C. Valenzuela and C. Galmarini},
  journal={PLoS ONE},
  year={2011},
  volume={6}
}
Irvalec is a marine-derived antitumor agent currently undergoing phase II clinical trials. In vitro, Irvalec induces a rapid loss of membrane integrity in tumor cells, accompanied of a significant Ca2+ influx, perturbations of membrane conductivity, severe swelling and the formation of giant membranous vesicles. All these effects are not observed in Irvalec-resistant cells, or are significantly delayed by pretreating the cells with Zn2+. Using fluorescent derivatives of Irvalec it was… Expand
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