Irs1 serine 307 promotes insulin sensitivity in mice.

@article{Copps2010Irs1S3,
  title={Irs1 serine 307 promotes insulin sensitivity in mice.},
  author={Kyle D. Copps and Nancy J Hançer and Lynn Opare-Ado and Wei Qiu and Cari Walsh and Morris F.WhiteM.F. White},
  journal={Cell metabolism},
  year={2010},
  volume={11 1},
  pages={
          84-92
        }
}
Phosphorylation of the insulin receptor substrates (Irs) on serine residues-typified by Ser307 of rodent Irs1-is thought to mediate insulin resistance. To determine whether Ser307 negatively regulates Irs1 in vivo, we generated knockin mice in which Ser307 (human Ser312) was replaced with alanine (A/A). Unexpectedly, A/A mice that were fed a high-fat diet developed more severe insulin resistance than control mice, accompanied by enhanced pancreatic compensation and impaired muscle insulin… CONTINUE READING
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