Irritable bowel syndrome: update on pathogenesis and management.

  title={Irritable bowel syndrome: update on pathogenesis and management.},
  author={Osama Habib Alaradi and Jamie S Barkin},
  journal={Medical principles and practice : international journal of the Kuwait University, Health Science Centre},
  volume={11 1},
Irritable bowel syndrome (IBS) comprises a major proportion of gastrointestinal and primary care practice worldwide. The past several years have seen the rapid evolution of a new and comprehensive model of IBS based on alterations in brain-gut interactions. Alterations in the bidirectional communication between the enteric nervous system and the central nervous system are implicated in the pathogenesis of IBS. 5-Hydroxytryptamine (5-HT; serotonin), a major neurotransmitter in the… CONTINUE READING

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