Irritable bowel syndrome: a review of the general aspects and the potential role of vitamin D

  title={Irritable bowel syndrome: a review of the general aspects and the potential role of vitamin D},
  author={Sandra Maria Barbalho and Ricardo de Alvares Goulart and Adriano Cressoni Ara{\'u}jo and {\'E}len Landgraf Guiguer and Marcelo Dib Bechara},
  journal={Expert Review of Gastroenterology \& Hepatology},
  pages={345 - 359}
ABSTRACT Introduction: Irritable Bowel Syndrome (IBS) is a bowel disorder leading to symptoms such as abdominal pain, modifications in the motility and bowel habits, distention, bloating, and gas. Vitamin D (VD) may interfere in a plethora of cellular mechanisms, and act directly or indirectly in the regulation of the microbiome, the release of anti-microbial peptides, modulation of the immune system and inflammation processes; which in turn, may positively interfere with the altered gut… 

Antibiotics, gut microbiota, and irritable bowel syndrome: What are the relations?

Analysis of data from cohort and case-control studies indicates that antibiotic treatment is associated with an increased risk of IBS, and contributes to a deeper understanding of the link between antibiotic use and the development of Ibs.

Dietary modulation of gut microbiota for the relief of irritable bowel syndrome

It appears that dietary modulation of the gut microbiota may be effective for the alleviation of IBS symptoms and, also an effective IBS management strategy based on the underlying mechanism; especially because, IBS currently has no specific treatment owing to its uncertain etiology.

Role of vitamin D in pediatric irritable bowel syndrome

This article reviews the association between vitamin D and IBS in children and elaborates on the possible mechanism of action of vitamin D.

The efficacy of vitamin D supplementation for irritable bowel syndrome: a systematic review with meta-analysis

It is suggested that vitamin D supplementation was superior to placebo for IBS treatment and an unstable pooled effect on IBS-TS was revealed.

Vitamin D3 Supplementation in Diarrhea-Predominant Irritable Bowel Syndrome Patients: The Effects on Symptoms Improvement, Serum Corticotropin-Releasing Hormone, and Interleukin-6 – A Randomized Clinical Trial

It is indicated that vitamin D3 supplementation can modulate the serum level of CRH and IL-6 and can improve symptoms in IBS-D patients.

Dynamics of clinical manifestations of irritable bowel syndrome against the background of cytoprotector rebamipide intake: intermediate results of the SOKRAT program

Protective therapy of epithelium with rebamipide has not only a symptom-reducing effect, but also a positive effect on the course of IBS, which led to an increase in the quality of life of the studied patients.

The use of vitamin D for patients with inflammatory bowel diseases.

  • Júlia Novaes MatiasVinícius Marinho Lima É. Guiguer
  • Medicine, Biology
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
  • 2022
There is still a need for standardized studies to establish how the supplementation of VD should be performed and the doses to be administered, as available clinical trials do not have standardization of doses and routes of administration.

Nutritional status in irritable bowel syndrome: A North American population‐based study

  • I. Hujoel
  • Medicine
    JGH open : an open access journal of gastroenterology and hepatology
  • 2020
The findings suggest that individuals with IBS should be screened for copper–zinc imbalance, and that zinc's role in the immune system, the “brain–gut” axis, and the gastrointestinal barrier, may play a role in perpetuating the underlying pathophysiology of IBS.

Association between irritable bowel syndrome and micronutrients: A systematic review

This work aimed to review the available literature on the effect of habitual and exclusion diets on micronutrient status as well as the role of micronsutrient supplementation in alleviating IBS symptoms.

Vitamin D supplementation for irritable bowel syndrome: A systematic review and meta‐analysis

This systematic review and meta‐analysis aimed to investigate the clinical effects of vitamin D supplementation on IBS symptom severity and quality of life (QoL) measures.



Letter: vitamin D supplementation and the irritable bowel syndrome

Vitamin D supplementation may have a beneficial effect in IBS patients with anti-proliferative, pro-differentiating, immunomodulatory and anti-inflammatory action, and chronic vitamin D deficiency may have serious adverse consequences.

Pathophysiology of irritable bowel syndrome.

The gut microbiome and irritable bowel syndrome

This review will highlight the data addressing the emerging role of the gut microbiome in the pathogenesis of IBS and review the evidence for current and future microbiome based treatments.

Associations between inflammatory bowel diseases and vitamin D

VD shows a potential role in the management of IBD, the supplementation is inexpensive, safe, and leads to improvement of the quality of life.

Therapeutic strategies for functional dyspepsia and irritable bowel syndrome based on pathophysiology

Understanding the origin of symptoms in FGIDs will allow therapy to be targeted at the pathophysiological changes, not at merely alleviating symptoms, and holds hope for eventual cure in some cases.

Vitamin D status in pediatric irritable bowel syndrome

Pediatric patients with IBS had significantly lower 25(OH)D concentration compared to controls despite having similar mean BMI values as controls, a much higher prevalence of vitamin D deficiency compared to IBD and other malabsorption syndromes.

Stress and the Microbiota–Gut–Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome

This review will highlight the evidence by which stress and the gut microbiota interact in the regulation of visceral nociception and the mechanisms by which microbiota can affect the stress response and behavioral outcomes with an emphasis on visceral pain.

Vitamin D3 as a novel treatment for irritable bowel syndrome: single case leads to critical analysis of patient-centred data

A case of a 41-year-old woman IBS sufferer who reported significant symptom improvements with high-dose vitamin D3 supplementation, and a systematic analysis of patient-centred, internet-based data surrounding this phenomenon.

New and emerging therapies for the treatment of irritable bowel syndrome: an update for gastroenterologists

Management that encompasses all aspects of irritable bowel syndrome (gastrointestinal symptoms) and comorbid psychologic symptoms (e.g. anxiety or depression) is important for improving overall patient health and well-being.